POPULATION-STRUCTURE OF THE HUMAN PSEUDOAUTOSOMAL BOUNDARY

被引：72
作者：
ELLIS, N
TAYLOR, A
BENGTSSON, BO
KIDD, J
ROGERS, J
GOODFELLOW, P
机构：
[1] LUND UNIV,DEPT GENET,S-22101 LUND,SWEDEN
[2] YALE UNIV,SCH MED,DEPT HUMAN GENET,NEW HAVEN,CT 06510
来源：
NATURE | 1990年 / 344卷 / 6267期
关键词：
D O I：
10.1038/344663a0
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
THE mammalian sex chromosomes are composed of two genetically distinct segments: the pseudoautosomal region, where recombination occurs between the X and Y chromosomes, and the sex chromosome-specific parts1,2. Between these two segments the human sex chromosomes differ by the insertion of an Alu element on the Y chromosome3. We have surveyed the sequence variation in the boundary region using the polymerase chain reaction. Fifty seven Y and sixty X chromosomes from ten different human populations were analysed. The X chromosomes were found to be polymorphic at five positions in a 300-base-pair region. By contrast, all Y chromosomes were identical except for one distal polymorphism shared with the X chromosome. © 1990 Nature Publishing Group.
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页码：663 / 665
页数：3
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