THE SYNTHESIS AND CONFORMATION IN SOLUTION OF CYCLO[L-PRO-L-LEU-L-(GLN)THZ-(GLY)THZ-L-VAL] (DOLASTATIN-3)

被引：21

作者：

HOLZAPFEL, CW ^{[1
]}

VANZYL, WJ ^{[1
]}

ROOS, M ^{[1
]}

机构：

[1] UNIV PRETORIA,DEPT CHEM,PRETORIA 0002,SOUTH AFRICA

来源：

TETRAHEDRON | 1990年 / 46卷 / 02期

关键词：

D O I：

10.1016/S0040-4020(01)85446-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Dolastatin 3, a unique cyclic peptide, was synthesised in high yield. Its minimum energy conformation in solution was established by NMR spectroscopy and force feild calculations, and is characterised by three intramolecular hydrogen bonds. © 1990.

引用

页码：649 / 660

页数：12

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