SYNERGISTIC EFFECT OF GANCICLOVIR AND FOSCARNET ON CYTOMEGALOVIRUS REPLICATION INVITRO

被引：110

作者：

MANISCHEWITZ, JF ^{[1
]}

QUINNAN, GV ^{[1
]}

LANE, HC ^{[1
]}

WITTEK, AE ^{[1
]}

机构：

[1] NIAID,CLIN IMMUNOL LAB,BETHESDA,MD 20892

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1990年 / 34卷 / 02期

关键词：

D O I：

10.1128/AAC.34.2.373

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Ganciclovir and foscarnet possess substantial activity against cytomegalovirus. Both exhibit dose-limiting toxicity, which reduces their clinical usefulness. We demonstrated synergistic inhibition of cytomegalovirus replication in vitro by ganciclovir and foscarnet. Reduced-dose combination therapy may provide a means to treat patients with cytomegalovirus infection while reducing drug toxicity.

引用

收藏

页码：373 / 375

页数：3

相关论文

共 20 条

[1]

Anhalt J.P., 1980, MANUAL CLIN MICROBIO, P478

[2] EFFECT OF ADENINE ARABINOSIDE ON CYTOMEGALOVIRUS INFECTIONS [J].

CHIEN, LT ;

CANNON, NJ ;

WHITLEY, RJ ;

DIETHELM, AG ;

DISMUKES, WE ;

SCOTT, CW ;

BUCHANAN, RA ;

ALFORD, CA .

JOURNAL OF INFECTIOUS DISEASES, 1974, 130 (01) :32-39

[3]

ELION GB, 1954, J BIOL CHEM, V208, P477

[4] CYTOMEGALO-VIRUS PNEUMONIA AFTER BONE-MARROW TRANSPLANTATION SUCCESSFULLY TREATED WITH THE COMBINATION OF GANCICLOVIR AND HIGH-DOSE INTRAVENOUS IMMUNE GLOBULIN [J].

EMANUEL, D ;

CUNNINGHAM, I ;

JULESELYSEE, K ;

BROCHSTEIN, JA ;

KERNAN, NA ;

LAVER, J ;

STOVER, D ;

WHITE, DA ;

FELS, A ;

POLSKY, B ;

CASTROMALASPINA, H ;

PEPPARD, JR ;

BARTUS, P ;

HAMMERLING, U ;

OREILLY, RJ .

ANNALS OF INTERNAL MEDICINE, 1988, 109 (10) :777-782

[5] TREATMENT OF CYTOMEGALOVIRUS PNEUMONITIS WITH FOSCARNET (TRISODIUM PHOSPHONOFORMATE) IN PATIENTS WITH AIDS [J].

FARTHING, C ;

ANDERSON, MG ;

ELLIS, ME ;

GAZZARD, BG ;

CHANAS, AC .

JOURNAL OF MEDICAL VIROLOGY, 1987, 22 (02) :157-162

[6] INFECTIOUS COMPLICATIONS OF THE ACQUIRED IMMUNE-DEFICIENCY SYNDROME [J].

GOLD, JWM ;

ARMSTRONG, D .

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1984, 437 (DEC) :383-393

[7] INTRAVENOUS FOSCARNET FOR THE TREATMENT OF SEVERE CYTOMEGALO-VIRUS INFECTION IN ALLOGRAFT RECIPIENTS [J].

KLINTMALM, G ;

LONNQVIST, B ;

OBERG, B ;

GAHRTON, G ;

LERNESTEDT, JO ;

LUNDGREN, G ;

RINGDEN, O ;

ROBERT, KH ;

WAHREN, B ;

GROTH, CG .

SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES, 1985, 17 (02) :157-163

[8] USE OF GANCICLOVIR TO TREAT SERIOUS CYTOMEGALOVIRUS INFECTIONS IN PATIENTS WITH AIDS [J].

LASKIN, OL ;

STAHLBAYLISS, CM ;

KALMAN, CM ;

ROSECAN, LR .

JOURNAL OF INFECTIOUS DISEASES, 1987, 155 (02) :323-327

[9] EFFECT OF 9-(1,3-DIHYDROXY-2-PROPOXYMETHYL)GUANINE ON HUMAN CYTOMEGALOVIRUS REPLICATION INVITRO [J].

MAR, EC ;

CHENG, YC ;

HUANG, ES .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1983, 24 (04) :518-521

[10] EFFECT OF 9-(1,3-DIHYDROXY-2-PROPOXYMETHYL) GUANINE ON SERIOUS CYTOMEGALOVIRUS DISEASE IN 8 IMMUNOSUPPRESSED HOMOSEXUAL MEN [J].

MASUR, H ;

LANE, HC ;

PALESTINE, A ;

SMITH, PD ;

MANISCHEWITZ, J ;

STEVENS, G ;

FUJIKAWA, L ;

MACHER, AM ;

NUSSENBLATT, R ;

BAIRD, B ;

MEGILL, M ;

WITTEK, A ;

QUINNAN, GV ;

PARRILLO, JE ;

ROOK, AH ;

ERON, LJ ;

PORETZ, DM ;

GOLDENBERG, RI ;

FAUCI, AS ;

GELMANN, EP .

ANNALS OF INTERNAL MEDICINE, 1986, 104 (01) :41-44