Formulation and characterization of self-nano emulsifying drug delivery systems of lemongrass (cymbopogon citratus) essential oil

被引：13

作者：

Ujilestari, Tri ^{[1
]}

Dono, Nanung Danar ^{[1
]}

Ariyadi, Bambang ^{[1
]}

Martien, Ronny ^{[2
]}

Zuprizal ^{[1
]}

机构：

[1] Univ Gadjah Mada, Fac Anim Sci, Dept Anim Nutr & Feed Sci, Yogyakarta, Indonesia

[2] Univ Gadjah Mada, Dept Pharmaceut, Fac Pharm, Yogyakarta, Indonesia

来源：

MALAYSIAN JOURNAL OF FUNDAMENTAL AND APPLIED SCIENCES | 2018年 / 14卷 / 03期

关键词：

Cymbopogon citratus; essential oil; nanoemulsion;

D O I：

10.11113/mjfas.v14n3.1070

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The present research was aimed to characterize the formula of self-nano emulsifying drug delivery systems (SNEDDS) for lemongrass essential oil. The observation variables included: particle size, zeta potential, and morphology. Meanwhile, the materials consisted of the mixtures of oils (lemongrass essential oil and carrier oil), surfactants, and cosurfactants. Carrier oils were screened as candidates for SNEDDS, and the formula was evaluated for transmittance and emulsification time. The value of the formulation component was lemongrass essential oils, carrier oil (Virgin Coconut Oil), surfactant (Tween 80), and co-surfactant (PEG 400) = 8.34, 8.34, 71.43, and 16.67% respectively. The formulation had a mean of the nanoemulsion droplet diameters of 20.7 nm with the polydispersity index (PI) 0.378 and potential zeta -73 mV. The transmission electron microscopy demonstrated spherical droplet morphology. This research produced SNEDDS of lemongrass essential oil with nanoparticle size that can be used as feed additive for poultry.

引用

页码：360 / 363

页数：4

共 34 条

[1]

Abouelkassem S., 2015, International Journal of Agriculture Innovations and Research, V4, P72

[2] Self nanoemulsifying drug delivery system (SNEDDS) of Rosuvastatin calcium: Design, formulation, bioavailability and pharmacokinetic evaluation [J].

Balakumar, Krishnamoorthy ;

Raghavan, Chellan Vijaya ;

Selvan, Natarajan Tamil ;

Prasad, Ranganathan Hari ;

Abdu, Siyad .

COLLOIDS AND SURFACES B-BIOINTERFACES, 2013, 112 :337-343

[3] Nanocarrier for the enhanced bioavailability of a cardiovascular agent: In vitro, pharmacodynamic, pharmacokinetic and stability assessment [J].

Bali, Vikas ;

Ali, Mushir ;

Ali, Javed .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2011, 403 (1-2) :46-56

[4] Optimized self nano-emulsifying systems of ezetimibe with enhanced bioavailability potential using long chain and medium chain triglycerides [J].

Bandyopadhyay, Shantanu ;

Katare, O. P. ;

Singh, Bhupinder .

COLLOIDS AND SURFACES B-BIOINTERFACES, 2012, 100 :50-61

[5] SNEDDS containing bioenhancers for improvement of dissolution and oral absorption of lacidipine. I: Development and optimization [J].

Basalious, Emad B. ;

Shawky, Nevine ;

Badr-Eldin, Shaimaa M. .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2010, 391 (1-2) :203-211

[6]

Chavda H., 2013, J POWDER TECHNOL, DOI [10.1155/2013/108569, DOI 10.1155/2013/108569]

[7]

Eid A, 2013, INT J PHARM PHARM SC, V5, P639

[8] Self-nanoemulsifying drug delivery systems of tamoxifen citrate: Design and optimization [J].

Elnaggar, Yosra S. R. ;

El-Massik, Magda A. ;

Abdallah, Ossama Y. .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2009, 380 (1-2) :133-141

[9] Effect of light and temperature on zeta potential and physical stability in solid lipid nanoparticle (SLN™) dispersions [J].

Freitas, C ;

Muller, RH .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1998, 168 (02) :221-229

[10]

Jeong Mi-Ran, 2009, Mycobiology, V37, P48, DOI 10.4489/MYCO.2009.37.1.048

← 1 2 3 4 →