COMBINED AMPHOTERICIN B-FLUCYTOSINE THERAPY IN ASPERGILLUS PNEUMONIA

被引：45
作者：
CODISH, SD
TOBIAS, JS
HANNIGAN, M
机构：
[1] HARVARD UNIV, SCH MED, DEPT SURG, BOSTON, MA 02115 USA
[2] ST BARTHOLOMEWS HOSP, DEPT MED ONCOL, LONDON EC1A 7BE, ENGLAND
[3] MT AUBURN HOSP, DEPT NURSING, CAMBRIDGE, MA 02138 USA
来源：
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION | 1979年 / 241卷 / 22期
关键词：
D O I：
10.1001/jama.241.22.2418
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The incidence of aspergillosis [in humans] is increasing while the prognosis remains dismal. Standard single-drug therapy with amphotericin B offers unacceptably low cure rates. A patient with Aspergillus pneumonia was treated with a synergistic combination of amphotericin B and flucytosine. A prompt clinical response and progressive resolution of the infection were observed. Combination therapy appeared to decrease the dose of amphotericin B needed for effective therapy. It may provide improved results with decreased toxic effects.
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页码：2418 / 2419
页数：2
相关论文
共 10 条
  • [1] CRYPTOCOCCAL MENINGITIS - FATAL MARROW APLASIA FROM COMBINED THERAPY
    BRYAN, CS
    MCFARLAND, JA
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1978, 239 (11): : 1068 - 1069
  • [2] MANAGING SYSTEMIC MYCOSES IN COMPROMISED HOST
    CODISH, SD
    TOBIAS, JS
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1976, 235 (19): : 2132 - 2134
  • [3] CODISH SD, 1979, SURG GYNECOL OBSTET, V148, P435
  • [4] CODISH SD, 1978, HOSP MED, V14, P6
  • [5] CODISH SD, 1978, HOSP MED, V14, P30
  • [6] Eilard T, 1976, J Antimicrob Chemother, V2, P239, DOI 10.1093/jac/2.3.239
  • [7] ASPERGILLUS PNEUMONIA IN HEMATOLOGIC MALIGNANCY - IMPROVEMENTS IN DIAGNOSIS AND THERAPY
    PENNINGTON, JE
    [J]. ARCHIVES OF INTERNAL MEDICINE, 1977, 137 (06) : 769 - 771
  • [8] SCHROTER GPJ, 1976, SURGERY, V79, P268
  • [9] THERAPY OF CRYPTOCOCCOSIS WITH A COMBINATION OF FLUCYTOSINE AND AMPHOTERICIN-B
    UTZ, JP
    GARRIQUES, IL
    SANDE, MA
    WARNER, JF
    MANDELL, GL
    MCGEHEE, RF
    DUMA, RJ
    SHADOMY, S
    [J]. JOURNAL OF INFECTIOUS DISEASES, 1975, 132 (04) : 368 - 373
  • [10] 1978, MED LETT, V20, P66
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