SURVIVAL OF THYROID-CELLS FOLLOWING IRRADIATION - DIRECTLY GENERATED SINGLE-DOSE SURVIVAL CURVE

被引:21
作者
DEMOTT, RK [1 ]
MULCAHY, RT [1 ]
CLIFTON, KH [1 ]
机构
[1] UNIV WISCONSIN,WISCONSIN CLIN CANC CTR,DEPT RADIOL,MADISON,WI 53706
关键词
D O I
10.2307/3575149
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
A method has been developed to generate a single-dose-radiation-cell-survival curve for rat thyroid gland cells. The technique employed relies on the quantitative transplantation of enzymatically prepared monodisposal cells into isologous recipient rat fat pads. The cells irradiated in vitro prior to implantation. A positive end point consists of the formation of morphologically and functionally normal thyroid follicles. The survival curve generated for the hormonal condition employed has a D0 of 190 rad and an extrapolation value of 4.
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页码:395 / 403
页数:9
相关论文
共 22 条
[1]  
ARMITAGE P, 1973, STATISTICAL METHODS
[2]   MOLECULAR THEORY OF CELL SURVIVAL [J].
CHADWICK, KH ;
LEENHOUTS, HP .
PHYSICS IN MEDICINE AND BIOLOGY, 1973, 18 (01) :78-87
[3]   SURVIVAL CHARACTERISTICS OF STEM CELLS OF GASTRIC-MUCOSA IN C3H MICE SUBJECTED TO LOCALIZED GAMMA-IRRADIATION [J].
CHEN, KY ;
WITHERS, HR .
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY AND RELATED STUDIES IN PHYSICS CHEMISTRY AND MEDICINE, 1972, 21 (06) :521-&
[4]  
CLIFTON KELLY H., 1963, INT J RADIAT BIOL, V7, P515, DOI 10.1080/09553006314551561
[5]   THYROID-GLAND FORMATION FROM INOCULA OF MONODISPERSED CELLS - EARLY RESULTS ON QUANTITATION, FUNCTION, NEOPLASIA AND RADIATION EFFECTS [J].
CLIFTON, KH ;
DEMOTT, RK ;
MULCAHY, RT ;
GOULD, MN .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1978, 4 (11-1) :987-990
[6]  
CLIFTON KH, 1976, BIOL ENV EFFECTS LOW, V1, P205
[7]  
ELKIND MM, 1967, RADIOBIOLOGY CULTURE, P85
[8]   SURVIVAL OF MOUSE SKIN EPITHELIAL CELLS FOLLOWING SINGLE AND DIVIDED DOSES OF X-RAYS [J].
EMERY, EW ;
DENEKAMP, J ;
BALL, MM .
RADIATION RESEARCH, 1970, 41 (03) :450-&
[9]   MORPHOLOGICAL AND QUANTITATIVE STUDIES OF GLAND FORMATION FROM INOCULA OF MONODISPERSED RAT MAMMARY CELLS [J].
GOULD, MN ;
BIEL, WF ;
CLIFTON, KH .
EXPERIMENTAL CELL RESEARCH, 1977, 107 (02) :405-416
[10]   SURVIVAL OF MAMMARY CELLS FOLLOWING IRRADIATION INVIVO - DIRECTLY GENERATED SINGLE-DOSE-SURVIVAL CURVE [J].
GOULD, MN ;
CLIFTON, KH .
RADIATION RESEARCH, 1977, 72 (02) :343-352