DETERMINATION OF VALPROATE IN THE PRESENCE OF FELBAMATE IN HUMAN PLASMA BY NARROW-BORE CAPILLARY GAS-CHROMATOGRAPHY

被引：5
作者：
ROMANYSHYN, LA [1 ]
WAGNER, MC [1 ]
WICHMANN, JK [1 ]
KUCHARCZYK, N [1 ]
SOFIA, RD [1 ]
机构：
[1] WALLACE LABS,DEPT BIOCHEM,DIV CARTER WALLACE,CRANBURY,NJ 08512
来源：
EPILEPSIA | 1994年 / 35卷 / 02期
关键词：
ANTICONVULSANTS; VALPROATE; FELBAMATE; PHARMACOKINETICS; DRUG INTERACTIONS; GAS CHROMATOGRAPHY;
D O I：
10.1111/j.1528-1157.1994.tb02453.x
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
A narrow bore capillary gas chromatographic method with one extraction step has been developed for quantitation of valproate (VPA) in the presence of felbamate (FBM) in human plasma. The method uses 0.250-ml aliquots of human plasma and one internal standard (IS). Chromatographic conditions include a DBWAX, 0.25 mm ID x 15 m, 0.25-mu m film thickness column; splitless injection; and flame ionization detection. The linear quantitation range for VPA is 1.00-256 mu g/ml.
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页码：406 / 410
页数：5
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