NEITHER CIMETIDINE NOR PROBENECID AFFECT THE PHARMACOKINETICS OF TENOXICAM IN NORMAL VOLUNTEERS

The effect of pretreatment with cimetidine (1 g day-1, 7 days) and of probenecid (1 g twice daily, 4 days) on the pharmacokinetics of tenoxicam (single oral dose, 20 mg) was studied in six healthy volunteers. C(max) was increased significantly when tenoxicam was given with probenecid (2.8 mug ml-1 alone, 3.5 mug ml-1 after probenecid; P < 0.005). No other pharmacokinetic parameters were altered significantly by either drug. It is concluded that neither cimetidine nor probenecid affects the pharmacokinetics of tenoxicam in a clinically important way.