BIOACTIVE COMPOUNDS FROM MARINE SPONGES

被引：45
作者：
HIGA, T
TANAKA, J
KITAMURA, A
KOYAMA, T
TAKAHASHI, M
UCHIDA, T
机构：
[1] Department of Marine Sciences, University of the Ryukyus, Nishihara
来源：
PURE AND APPLIED CHEMISTRY | 1994年 / 66卷 / 10-11期
关键词：
D O I：
10.1351/pac199466102227
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Several marine sponges from Okinawan waters have been examined for bioactive compounds. Further investigation with Polyfibrospongia sp. which have already yielded novel metabolites gave new hennoxazoles (6-9), of which 7 was moderately cytotoxic. Echinoclathria sp. furnished new pyridine alkaloids (10-12), two of which showed immunosuppressive activity. A sponge identified to be Dysidea herbacea afforded cytotoxic 20,24-dimethyldeoxoscalarin-3-one (14) along with known diterpenes. Two cytotoxic dimers (15,16) of a sesquiterpene have been isolated from Halichondria sp. Mytiloxanthin derivatives (18,19) were the major pigments of Phakellia stelliderma. A new species of the family Niphatidae gave highly cytotoxic polyacetylenes (20-26).
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页码：2227 / 2230
页数：4
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