INTRAGASTRIC TRYPTOPHAN REDUCES GLYCEMIA AFTER GLUCOSE, POSSIBLY VIA GLUCOSE-MEDIATED INSULINOTROPIC POLYPEPTIDE, IN EARLY-WEANED PIGLETS

被引:22
|
作者
PONTER, AA
SEVE, B
MORGAN, LM
机构
[1] INRA,RECH PORCINES STN,F-35590 HERMITAGE,FRANCE
[2] UNIV SURREY,SCH BIOL SCI,GUILDFORD GU2 5XH,SURREY,ENGLAND
来源
JOURNAL OF NUTRITION | 1994年 / 124卷 / 02期
关键词
TRYPTOPHAN; PIGLETS; ENTEROINSULAR AXIS;
D O I
10.1093/jn/124.2.259
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
The aim of this experiment was to investigate the influence of oral tryptophan on insulin, glucose-mediated insulinotropic polypeptide and glucose concentrations in early-weaned piglets. Piglets were given by intragastric infusion, at the same level of feeding, either a tryptophan-deficient or tryptophan-adequate diet for 22 d. During the experiment blood samples were taken after intragastric infusion of 1) the accustomed meal, 2) a glucose plus tryptophan load and 3) a glucose load. Plasma samples were analyzed for insulin, glucose-mediated insulinotropic polypeptide, glucose and lactate. After the accustomed meal plasma insulin concentrations were augmented and liquid gastric emptying faster in pigs fed tryptophan-adequate compared with tryptophan-deficient diets (P < 0.05) but glucose-mediated insulinotcopic polypeptide, glucose and lactate were unaffected. The addition of tryptophan to a glucose load increased glucose-mediated insulinotropic polypeptide and reduced glucose in both tryptophan-adequate and tryptophan-deficient diet fed pigs (P < 0.05). Piglets adapted to the tryptophan-adequate diet had a greater glucose-mediated insulinotropic polypeptide response to intragastric glucose plus tryptophan than piglets adapted to the tryptophan-deficient diet. Adaptation to a tryptophan-adequate diet seems to increase the release of glucose-mediated insulinotropic polypeptide due to infusion of a tryptophan-adequate compared with a tryptophan-deficient diet. The addition of tryptophan to a glucose load reduces the level of glycemia, possibly through glucose-mediated insulinotropic polypeptide-mediated glucose disposal.
引用
收藏
页码:259 / 267
页数:9
相关论文
共 4 条
  • [1] Effects of long-term parenteral administration of vitamin B6 on B6 status and some aspects of the glucose and protein metabolism of early-weaned piglets
    Matte, JJ
    Girard, CL
    Sève, B
    BRITISH JOURNAL OF NUTRITION, 2001, 85 (01) : 11 - 21
  • [2] Glucose-dependent insulinotropic polypeptide activates the Raf-Mek1/2-ERK1/2 module via a cyclic AMP/cAMP-dependent protein kinase/Rap1-mediated pathway
    Ehses, JA
    Pelech, SL
    Pederson, RA
    McIntosh, CHS
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (40) : 37088 - 37097
  • [3] Glucose-dependent insulinotropic polypeptide promotes β-(INS-1) cell survival via cyclic adenosine monophosphate-mediated caspase-3 inhibition and regulation of p38 mitogen-activated protein kinase
    Ehses, JA
    Casilla, VR
    Doty, T
    Pospisilik, JA
    Winter, KD
    Demuth, HU
    Pederson, RA
    McIntosh, CHS
    ENDOCRINOLOGY, 2003, 144 (10) : 4433 - 4445
  • [4] Suppression of p38 MAPK and JNK via Akt-mediated Inhibition of Apoptosis Signal-regulating Kinase 1 Constitutes a Core Component of the β-Cell Pro-survival Effects of Glucose-dependent Insulinotropic Polypeptide
    Widenmaier, Scott B.
    Ao, Ziliang
    Kim, Su-Jin
    Warnock, Garth
    McIntosh, Christopher H. S.
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2009, 284 (44) : 30372 - 30382