共 4 条
INTRAGASTRIC TRYPTOPHAN REDUCES GLYCEMIA AFTER GLUCOSE, POSSIBLY VIA GLUCOSE-MEDIATED INSULINOTROPIC POLYPEPTIDE, IN EARLY-WEANED PIGLETS
被引:22
|作者:
PONTER, AA
SEVE, B
MORGAN, LM
机构:
[1] INRA,RECH PORCINES STN,F-35590 HERMITAGE,FRANCE
[2] UNIV SURREY,SCH BIOL SCI,GUILDFORD GU2 5XH,SURREY,ENGLAND
来源:
JOURNAL OF NUTRITION
|
1994年
/
124卷
/
02期
关键词:
TRYPTOPHAN;
PIGLETS;
ENTEROINSULAR AXIS;
D O I:
10.1093/jn/124.2.259
中图分类号:
R15 [营养卫生、食品卫生];
TS201 [基础科学];
学科分类号:
100403 ;
摘要:
The aim of this experiment was to investigate the influence of oral tryptophan on insulin, glucose-mediated insulinotropic polypeptide and glucose concentrations in early-weaned piglets. Piglets were given by intragastric infusion, at the same level of feeding, either a tryptophan-deficient or tryptophan-adequate diet for 22 d. During the experiment blood samples were taken after intragastric infusion of 1) the accustomed meal, 2) a glucose plus tryptophan load and 3) a glucose load. Plasma samples were analyzed for insulin, glucose-mediated insulinotropic polypeptide, glucose and lactate. After the accustomed meal plasma insulin concentrations were augmented and liquid gastric emptying faster in pigs fed tryptophan-adequate compared with tryptophan-deficient diets (P < 0.05) but glucose-mediated insulinotcopic polypeptide, glucose and lactate were unaffected. The addition of tryptophan to a glucose load increased glucose-mediated insulinotropic polypeptide and reduced glucose in both tryptophan-adequate and tryptophan-deficient diet fed pigs (P < 0.05). Piglets adapted to the tryptophan-adequate diet had a greater glucose-mediated insulinotropic polypeptide response to intragastric glucose plus tryptophan than piglets adapted to the tryptophan-deficient diet. Adaptation to a tryptophan-adequate diet seems to increase the release of glucose-mediated insulinotropic polypeptide due to infusion of a tryptophan-adequate compared with a tryptophan-deficient diet. The addition of tryptophan to a glucose load reduces the level of glycemia, possibly through glucose-mediated insulinotropic polypeptide-mediated glucose disposal.
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页码:259 / 267
页数:9
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