AN APPROACH TO THE SYNTHESIS OF (-)-LIPSTATIN BY WITTIG REACTION AND LEWIS ACID-PROMOTED [2+2] CYCLOADDITION

被引：22

作者：

PONS, JM ^{[1
]}

POMMIER, A ^{[1
]}

LERPINIERE, J ^{[1
]}

KOCIENSKI, P ^{[1
]}

机构：

[1] UNIV SOUTHAMPTON,DEPT CHEM,SOUTHAMPTON SO9 5NH,HANTS,ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1993年 / 14期

关键词：

D O I：

10.1039/p19930001549

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The beta-lactone moiety of (-)-lipstatin 1, a potent inhibitor of pancreatic lipase, is prepared via a Lewis acid-promoted [2 + 2] cycloaddition between hexyltrimethylsilyl ketene 3 and the (Z,Z)-dienic aldehyde 4, obtained from hexanal by two stereoselective Wittig reactions.

引用

页码：1549 / 1551

页数：3

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