CHROMOSOMAL LOCALIZATION OF FLT4, A NOVEL RECEPTOR-TYPE TYROSINE KINASE GENE

被引：69
作者：
GALLAND, F
KARAMYSHEVA, A
MATTEI, MG
ROSNET, O
MARCHETTO, S
BIRNBAUM, D
机构：
[1] INSERM,U119,MOLEC ONCOL LAB,27 BLVD LEI ROURE,F-13009 MARSEILLE,FRANCE
[2] HOP ENFANTS LA TIMONE,INSERM,U242,F-13385 MARSEILLE 5,FRANCE
来源：
GENOMICS | 1992年 / 13卷 / 02期
关键词：
D O I：
10.1016/0888-7543(92)90277-Y
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
A new human gene encoding a putative receptor-type tyrosine kinase (RTK) was isolated by screening a placenta cDNA library with a mouse Flt3 probe. The deduced amino acid sequence of the intracellular region of the molecule showed that it was strongly related to the FLT1 and KDR FLK1 gene products and to a lesser degree to members of the class III RTKs FMS CSF1R, PDGFRA B, KIT, and FLT3. The gene was named FLT4 Cosmid clones of the mouse Flt4 gene were isolated. The human gene was localized to bands q34-q35 of chromosome 5, i.e., slightly telomeric to the CSF1R PDGFRB tandem of genes, and the mouse homolog to chromosome 11, region A5-B1. © 1992.
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页码：475 / 478
页数：4
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