Plasma and other body fluids contain cell-derived extracellular vesicles (EVs), which participate in physiopathological processes and have potential biomedical applications. In order to isolate, concentrate and purify EVs, high-speed centrifugation is often used. We show here, using electron microscopy, receptor-specific gold labelling and flow cytometry, that high-speed centrifugation induces the formation of EV aggregates composed of a mixture of EVs of various phenotypes and morphologies. The presence of aggregates made of EVs of different phenotypes may lead to erroneous interpretation concerning the existence of EVs harbouring surface antigens from different cell origins.
机构:
Michael E DeBakey VA Med Ctr, Houston, TX 77030 USA
Baylor Coll Med, Dept Pathol, Houston, TX 77030 USAMichael E DeBakey VA Med Ctr, Houston, TX 77030 USA
Dasgupta, Swapan K.
Abdel-Monem, Hanan
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机构:
Michael E DeBakey VA Med Ctr, Houston, TX 77030 USA
Baylor Coll Med, Dept Pathol, Houston, TX 77030 USAMichael E DeBakey VA Med Ctr, Houston, TX 77030 USA
Abdel-Monem, Hanan
Niravath, Polly
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Baylor Coll Med, Dept Med, Houston, TX 77030 USAMichael E DeBakey VA Med Ctr, Houston, TX 77030 USA
Niravath, Polly
Le, Anhquyen
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机构:
Michael E DeBakey VA Med Ctr, Houston, TX 77030 USA
Baylor Coll Med, Dept Pathol, Houston, TX 77030 USAMichael E DeBakey VA Med Ctr, Houston, TX 77030 USA
Le, Anhquyen
Bellera, Ricardo V.
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Baylor Coll Med, Dept Pediat, Houston, TX 77030 USAMichael E DeBakey VA Med Ctr, Houston, TX 77030 USA
Bellera, Ricardo V.
Langlois, Kimberly
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Baylor Coll Med, Dept Pediat, Houston, TX 77030 USAMichael E DeBakey VA Med Ctr, Houston, TX 77030 USA
Langlois, Kimberly
Nagata, Shigekazu
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Osaka Univ, Sch Med, Dept Genet, Osaka, JapanMichael E DeBakey VA Med Ctr, Houston, TX 77030 USA
Nagata, Shigekazu
Rumbaut, Rolando E.
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机构:
Michael E DeBakey VA Med Ctr, Houston, TX 77030 USA
Baylor Coll Med, Dept Pathol, Houston, TX 77030 USA
Baylor Coll Med, Dept Pediat, Houston, TX 77030 USAMichael E DeBakey VA Med Ctr, Houston, TX 77030 USA
Rumbaut, Rolando E.
Thiagarajan, Perumal
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机构:
Michael E DeBakey VA Med Ctr, Houston, TX 77030 USA
Baylor Coll Med, Dept Pathol, Houston, TX 77030 USA
Baylor Coll Med, Dept Med, Houston, TX 77030 USAMichael E DeBakey VA Med Ctr, Houston, TX 77030 USA
机构:
Michael E DeBakey VA Med Ctr, Houston, TX 77030 USA
Baylor Coll Med, Dept Pathol, Houston, TX 77030 USAMichael E DeBakey VA Med Ctr, Houston, TX 77030 USA
Dasgupta, Swapan K.
Abdel-Monem, Hanan
论文数: 0引用数: 0
h-index: 0
机构:
Michael E DeBakey VA Med Ctr, Houston, TX 77030 USA
Baylor Coll Med, Dept Pathol, Houston, TX 77030 USAMichael E DeBakey VA Med Ctr, Houston, TX 77030 USA
Abdel-Monem, Hanan
Niravath, Polly
论文数: 0引用数: 0
h-index: 0
机构:
Baylor Coll Med, Dept Med, Houston, TX 77030 USAMichael E DeBakey VA Med Ctr, Houston, TX 77030 USA
Niravath, Polly
Le, Anhquyen
论文数: 0引用数: 0
h-index: 0
机构:
Michael E DeBakey VA Med Ctr, Houston, TX 77030 USA
Baylor Coll Med, Dept Pathol, Houston, TX 77030 USAMichael E DeBakey VA Med Ctr, Houston, TX 77030 USA
Le, Anhquyen
Bellera, Ricardo V.
论文数: 0引用数: 0
h-index: 0
机构:
Baylor Coll Med, Dept Pediat, Houston, TX 77030 USAMichael E DeBakey VA Med Ctr, Houston, TX 77030 USA
Bellera, Ricardo V.
Langlois, Kimberly
论文数: 0引用数: 0
h-index: 0
机构:
Baylor Coll Med, Dept Pediat, Houston, TX 77030 USAMichael E DeBakey VA Med Ctr, Houston, TX 77030 USA
Langlois, Kimberly
Nagata, Shigekazu
论文数: 0引用数: 0
h-index: 0
机构:
Osaka Univ, Sch Med, Dept Genet, Osaka, JapanMichael E DeBakey VA Med Ctr, Houston, TX 77030 USA
Nagata, Shigekazu
Rumbaut, Rolando E.
论文数: 0引用数: 0
h-index: 0
机构:
Michael E DeBakey VA Med Ctr, Houston, TX 77030 USA
Baylor Coll Med, Dept Pathol, Houston, TX 77030 USA
Baylor Coll Med, Dept Pediat, Houston, TX 77030 USAMichael E DeBakey VA Med Ctr, Houston, TX 77030 USA
Rumbaut, Rolando E.
Thiagarajan, Perumal
论文数: 0引用数: 0
h-index: 0
机构:
Michael E DeBakey VA Med Ctr, Houston, TX 77030 USA
Baylor Coll Med, Dept Pathol, Houston, TX 77030 USA
Baylor Coll Med, Dept Med, Houston, TX 77030 USAMichael E DeBakey VA Med Ctr, Houston, TX 77030 USA