LOCALIZATION OF ANTIGENIC DETERMINANTS IN POLYPEPTIDE CHAINS OF COLLAGEN

被引：61

作者：

MICHAELI, D

MARTIN, GR

KETTMAN, J

BENJAMIN.E

LEUNG, DYK

BLATT, BA

机构：

[1] Laboratory of Medical Entomology, Kaiser Foundation Research Institute, San Francisco, CA

[2] Laboratory of Biochemistry, National Institute of Dental Research, Bethesda, MD

来源：

SCIENCE | 1969年 / 166卷 / 3912期

关键词：

D O I：

10.1126/science.166.3912.1522

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

After being injected with collagen from rat or guinea pig skin, rabbits form high titer, species-specific antibodies to collagen. Antibody is directed primarily against the α2 chain of collagen with little reaction with the α1 chain. The amino terminal peptide of cyanogen bromide cleavage of the α2 chain of guinea pig skin collagen, α2-CBl, effectively inhibited the antigen-antibody reaction, an indication that a major antigenic determinant of collagen is located at the amino terminal of the α2 chain.

引用

页码：1522 / &

共 13 条

[1] NATURE OF INTRAMOLECULAR CROSS-LINKS IN COLLAGEN . SEPARATION AND CHARACTERIZATION OF PEPTIDES FROM CROSS-LINK REGION OF RAT SKIN COLLAGEN [J].