NO EVIDENCE FOR THE EXISTENCE OF PREFORMED ANTIBODIES AGAINST HYDROXYETHYL STARCH IN MAN

被引：18

作者：

KRAFT, D

SIRTL, C

LAUBENTHAL, H

SCHEINER, O

PARTH, E

DIETERICH, HJ

SZEPFALUSI, Z

TRAMPISCH, HJ

GERLACH, E

PETER, K

机构：

[1] RUHR UNIV BOCHUM,DEPT MED STAT,W-4630 BOCHUM,GERMANY

[2] UNIV MUNICH,DEPT PHYSIOL,W-8000 MUNICH 2,GERMANY

[3] ST JOSEF HOSP,ANAESTHESIOL CLIN,BOCHUM,GERMANY

[4] INST ANAESTHESIOL,MUNICH,GERMANY

来源：

EUROPEAN SURGICAL RESEARCH | 1992年 / 24卷 / 03期

关键词：

HYDROXYETHYL STARCH; COLLOID SOLUTIONS; ANAPHYLACTOID REACTIONS; ENZYME-LINKED IMMUNOSORBENT ASSAY; HYDROXYETHYL STARCH-REACTIVE ANTIBODIES;

D O I：

10.1159/000129200

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Using the highly sensitive ELISA technique for detecting anti-hydroxyethyl starch (HES) antibodies in man sera from 1,056 patients were analyzed. Patients of both sex, who had never had any prior contact with HES, were included in the study. In none of the cases could any titer of HES-reactive antibodies be detected. These data suggest that in man preformed HES-reactive antibodies do not exist or are extremely rare. In any case, unlike dextran-reactive antibodies, they should not have a high clinical importance. The mechanism behind the very rarely observed anaphylactoid reactions after HES application is still unknown.

引用

页码：138 / 142

页数：5

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