INFLUENCE OF PH ON PHOSPHATIDIC-ACID MULTILAYERS - RIPPLED STRUCTURE AT HIGH PH VALUES

被引：32

作者：

HARLOS, K

STUMPEL, J

EIBL, H

机构：

[1] Max-Planck-Institut für Biophysikalische Chemie

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1979年 / 555卷 / 03期

关键词：

(Freeze-fracture; Differential scanning calorimetry); pH dependence; Phosphatidic acid; Phospholipid pretransition;

D O I：

10.1016/0005-2736(79)90394-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The influence of pH on the structure of 1,2-(ditetradecyl)-phosphatidic acid was investigated by differential scanning calorimetry and freeze-fracture electron microscopy. At pH 13.5-14 (2.6 M K+), where phosphatidic acid has two negative charges, calorimetric scans show a small transition (pretransition) below the main phase transition temperature. Freeze-fracture studies of the same dispersions reveal regular band patterns (so-called ripples) in the plane of the bilayers, when the lipid is quenched from below the main phase transition temperature. This rippled structure is similar to the well-known rippled structure of phosphatidylcholines. © 1979.

引用

页码：409 / 416

页数：8

共 30 条

[1]

BLUME A, 1976, THESIS U FREIBURG

[2]

CHAPMAN D, 1974, J BIOL CHEM, V249, P2512

[3]

CHAPMAN D., 1967, CHEM PHYS LIPIDS, V1, P445, DOI 10.1016/0009-3084(67)90023-0

[4] PHOSPHORYLATION OF 1-ALKENYL-2-ACYLGLYCEROL AND PREPARATION OF 2-ACYLPHOSPHOGLYCERIDES [J].