SUBCELLULAR LOCALIZATION OF PTEROYL POLYGLUTAMATE HYDROLASE AND FOLATE IN GUINEA PIG INTESTINAL MUCOSA

被引：84
作者：
HOFFBRAN.AV
PETERS, TJ
机构：
来源：
BIOCHIMICA ET BIOPHYSICA ACTA | 1969年 / 192卷 / 03期
关键词：
D O I：
10.1016/0304-4165(69)90397-3
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
1. 1. Guinea pig intestinal mucosa was fractionated by two methods and the subcellular localization of pteroyl polyglutamate hydrolase (formerly known as folate conjugase) was determined. 2. 2. Pteroyl polyglutamate hydrolase appeared to be localized predominantly in the lysosomal fraction: no significant brush-border localization of the enzyme was noted. 3. 3. Folate was concentrated in the mitochondrial fraction. 4. 4. Possible mechanisms of pteroyl polyglutamate absorption are discussed in the light of the findings. © 1969.
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页码：479 / &
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