SUPPRESSION OF PRESSOR RESPONSE DURING LARYNGOSCOPY AND ENDOTRACHEAL INTUBATION BY ESMOLOL ADMINISTERED IN DOSES OF 1.5 mg/kg, 2.25 mg/kg: A COMPARATIVE CLINICAL STUDY

BACKGROUND Laryngoscopy and endotracheal intubation results in physiological changes of various body systems like heart rate and blood pressure in cardiovascular system. For attenuating the hyperdynamic cardiovascular response to tracheal intubation, numerous trials with many drugs were undertaken. AIM Of our study is to find out the safety and efficacy of attenuation of pressor response during laryngoscopy and tracheal intubation using Esmolol, administered as single intravenous bolus prior to induction of anaesthesia in two different doses of 1.5 mg/kg and 2.25 mg/kg. Control group was considered in our previous study using the same drug with different dosage, i.e. a dose of 0.75 mg/kg was compared with a placebo. We would like to go ahead with further increase in the dosage per kg body weight to get an ideal suppression of the pressor responses. MATERIALS AND METHODS The study was conducted in 50 patients, who were randomly assigned into 2 groups of 25 each. Group A (25) received Inj. Esmolol 1.5 mg/kg and Group B (25) received Inj. Esmolol 2.25 mg/kg IV before induction. RESULTS Heart rate and blood pressures were well maintained within physiological range in Group A, whereas there was a decrease in blood pressure and heart rate in the Group B immediately after intubation and at the end of 4th min. CONCLUSION In this study, the Group B showed an inappropriate decrease in mean values of Heart Rate, Blood Pressure immediately after administration.