Bisphosphonates;
Er: YAG laser;
Low level laser therapy;
Nd: YAG laser;
Osteonecrosis of the jaw;
D O I:
10.1016/j.cadmos.2011.05.007
中图分类号:
R78 [口腔科学];
学科分类号:
1003 ;
摘要:
Objectives. Osteonecrosis of the jaw (ONJ) is a side effect of bisphosphonate therapy (BPT) that was first described in 2003. The etiology of BPTassociated ONJ (BRONJ) remains unknown, but the pathogenesis seems to be related to multiple local and general factors. Several groups of experts have developed prevention protocols to facilitate specialists involved in the multidisciplinary management of patients with BRONJ. This paper provides a concise review of the literature on BRONJ and describes our experience at the University of Parma with 160 patients who received BPT for neoplastic and non-neoplastic diseases. Materials and methods. 139 BRONJ sites in 160 patients were treated with 5 different approaches, as follows: Group 1, 28 sites treated with medical therapy alone; Group 2, 32 sites treated with medical therapy and Low-Level Laser Therapy (LLLT); Group 3, 17 sites treated with medical therapy and conventional surgery; Group 4, 33 sites treated with medical therapy, surgery, and traditional LLLT; and Group 5, 29 sites treated with medical therapy, laser-assisted surgery, and LLLT. Results and conclusions. In terms of clinical improvement, statistically significant differences were found between the different treatment groups and those treated with medical therapy alone. The introduction of laser-assisted therapy and surgical approaches seem to produce better results in terms of complete healing.
机构:
UCL, Eastman Dent Inst, Oral Med Unit, Div Maxillofacial Diagnost Med & Surg Sci, London WC1X 8LD, EnglandUCL, Eastman Dent Inst, Oral Med Unit, Div Maxillofacial Diagnost Med & Surg Sci, London WC1X 8LD, England
Fedele, Stefano
;
Porter, Stephen R.
论文数: 0引用数: 0
h-index: 0
机构:UCL, Eastman Dent Inst, Oral Med Unit, Div Maxillofacial Diagnost Med & Surg Sci, London WC1X 8LD, England
Porter, Stephen R.
;
D'Aiuto, Francesco
论文数: 0引用数: 0
h-index: 0
机构:UCL, Eastman Dent Inst, Oral Med Unit, Div Maxillofacial Diagnost Med & Surg Sci, London WC1X 8LD, England
D'Aiuto, Francesco
;
Aljohani, Suad
论文数: 0引用数: 0
h-index: 0
机构:UCL, Eastman Dent Inst, Oral Med Unit, Div Maxillofacial Diagnost Med & Surg Sci, London WC1X 8LD, England
Aljohani, Suad
;
Vescovi, Paolo
论文数: 0引用数: 0
h-index: 0
机构:
Univ Parma, Unit Oral Med Pathol Laser Assisted Surgery Parma, I-43100 Parma, ItalyUCL, Eastman Dent Inst, Oral Med Unit, Div Maxillofacial Diagnost Med & Surg Sci, London WC1X 8LD, England
Vescovi, Paolo
;
Manfredi, Maddalena
论文数: 0引用数: 0
h-index: 0
机构:
Univ Parma, Unit Oral Med Pathol Laser Assisted Surgery Parma, I-43100 Parma, ItalyUCL, Eastman Dent Inst, Oral Med Unit, Div Maxillofacial Diagnost Med & Surg Sci, London WC1X 8LD, England
Manfredi, Maddalena
;
Arduino, Paolo G.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Turin, Lingotto Dent Inst, Oral Med Sect, Dept Biomed Sci & Human Oncol, Turin, ItalyUCL, Eastman Dent Inst, Oral Med Unit, Div Maxillofacial Diagnost Med & Surg Sci, London WC1X 8LD, England
Arduino, Paolo G.
;
Broccoletti, Roberto
论文数: 0引用数: 0
h-index: 0
机构:
Univ Turin, Lingotto Dent Inst, Oral Med Sect, Dept Biomed Sci & Human Oncol, Turin, ItalyUCL, Eastman Dent Inst, Oral Med Unit, Div Maxillofacial Diagnost Med & Surg Sci, London WC1X 8LD, England
Broccoletti, Roberto
;
Musciotto, Anna
论文数: 0引用数: 0
h-index: 0
机构:
Univ Palermo, Dept Stomatol Sci, Oral Med Sect, Palermo, ItalyUCL, Eastman Dent Inst, Oral Med Unit, Div Maxillofacial Diagnost Med & Surg Sci, London WC1X 8LD, England
Musciotto, Anna
;
Di Fede, Olga
论文数: 0引用数: 0
h-index: 0
机构:
Univ Palermo, Dept Stomatol Sci, Oral Med Sect, Palermo, ItalyUCL, Eastman Dent Inst, Oral Med Unit, Div Maxillofacial Diagnost Med & Surg Sci, London WC1X 8LD, England
Di Fede, Olga
;
Lazarovici, Tony S.
论文数: 0引用数: 0
h-index: 0
机构:
Chaim Sheba Med Ctr, Dept Oral & Maxillofacial Surg, IL-52621 Tel Hashomer, IsraelUCL, Eastman Dent Inst, Oral Med Unit, Div Maxillofacial Diagnost Med & Surg Sci, London WC1X 8LD, England
Lazarovici, Tony S.
;
Campisi, Giuseppina
论文数: 0引用数: 0
h-index: 0
机构:
Univ Palermo, Dept Stomatol Sci, Oral Med Sect, Palermo, ItalyUCL, Eastman Dent Inst, Oral Med Unit, Div Maxillofacial Diagnost Med & Surg Sci, London WC1X 8LD, England
Campisi, Giuseppina
;
Yarom, Naom
论文数: 0引用数: 0
h-index: 0
机构:
Chaim Sheba Med Ctr, Dept Oral & Maxillofacial Surg, IL-52621 Tel Hashomer, Israel
Tel Aviv Univ, Sch Dent Med, Dept Oral Pathol & Oral Med, IL-69978 Tel Aviv, IsraelUCL, Eastman Dent Inst, Oral Med Unit, Div Maxillofacial Diagnost Med & Surg Sci, London WC1X 8LD, England
机构:
UCL, Eastman Dent Inst, Oral Med Unit, Div Maxillofacial Diagnost Med & Surg Sci, London WC1X 8LD, EnglandUCL, Eastman Dent Inst, Oral Med Unit, Div Maxillofacial Diagnost Med & Surg Sci, London WC1X 8LD, England
Fedele, Stefano
;
Porter, Stephen R.
论文数: 0引用数: 0
h-index: 0
机构:UCL, Eastman Dent Inst, Oral Med Unit, Div Maxillofacial Diagnost Med & Surg Sci, London WC1X 8LD, England
Porter, Stephen R.
;
D'Aiuto, Francesco
论文数: 0引用数: 0
h-index: 0
机构:UCL, Eastman Dent Inst, Oral Med Unit, Div Maxillofacial Diagnost Med & Surg Sci, London WC1X 8LD, England
D'Aiuto, Francesco
;
Aljohani, Suad
论文数: 0引用数: 0
h-index: 0
机构:UCL, Eastman Dent Inst, Oral Med Unit, Div Maxillofacial Diagnost Med & Surg Sci, London WC1X 8LD, England
Aljohani, Suad
;
Vescovi, Paolo
论文数: 0引用数: 0
h-index: 0
机构:
Univ Parma, Unit Oral Med Pathol Laser Assisted Surgery Parma, I-43100 Parma, ItalyUCL, Eastman Dent Inst, Oral Med Unit, Div Maxillofacial Diagnost Med & Surg Sci, London WC1X 8LD, England
Vescovi, Paolo
;
Manfredi, Maddalena
论文数: 0引用数: 0
h-index: 0
机构:
Univ Parma, Unit Oral Med Pathol Laser Assisted Surgery Parma, I-43100 Parma, ItalyUCL, Eastman Dent Inst, Oral Med Unit, Div Maxillofacial Diagnost Med & Surg Sci, London WC1X 8LD, England
Manfredi, Maddalena
;
Arduino, Paolo G.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Turin, Lingotto Dent Inst, Oral Med Sect, Dept Biomed Sci & Human Oncol, Turin, ItalyUCL, Eastman Dent Inst, Oral Med Unit, Div Maxillofacial Diagnost Med & Surg Sci, London WC1X 8LD, England
Arduino, Paolo G.
;
Broccoletti, Roberto
论文数: 0引用数: 0
h-index: 0
机构:
Univ Turin, Lingotto Dent Inst, Oral Med Sect, Dept Biomed Sci & Human Oncol, Turin, ItalyUCL, Eastman Dent Inst, Oral Med Unit, Div Maxillofacial Diagnost Med & Surg Sci, London WC1X 8LD, England
Broccoletti, Roberto
;
Musciotto, Anna
论文数: 0引用数: 0
h-index: 0
机构:
Univ Palermo, Dept Stomatol Sci, Oral Med Sect, Palermo, ItalyUCL, Eastman Dent Inst, Oral Med Unit, Div Maxillofacial Diagnost Med & Surg Sci, London WC1X 8LD, England
Musciotto, Anna
;
Di Fede, Olga
论文数: 0引用数: 0
h-index: 0
机构:
Univ Palermo, Dept Stomatol Sci, Oral Med Sect, Palermo, ItalyUCL, Eastman Dent Inst, Oral Med Unit, Div Maxillofacial Diagnost Med & Surg Sci, London WC1X 8LD, England
Di Fede, Olga
;
Lazarovici, Tony S.
论文数: 0引用数: 0
h-index: 0
机构:
Chaim Sheba Med Ctr, Dept Oral & Maxillofacial Surg, IL-52621 Tel Hashomer, IsraelUCL, Eastman Dent Inst, Oral Med Unit, Div Maxillofacial Diagnost Med & Surg Sci, London WC1X 8LD, England
Lazarovici, Tony S.
;
Campisi, Giuseppina
论文数: 0引用数: 0
h-index: 0
机构:
Univ Palermo, Dept Stomatol Sci, Oral Med Sect, Palermo, ItalyUCL, Eastman Dent Inst, Oral Med Unit, Div Maxillofacial Diagnost Med & Surg Sci, London WC1X 8LD, England
Campisi, Giuseppina
;
Yarom, Naom
论文数: 0引用数: 0
h-index: 0
机构:
Chaim Sheba Med Ctr, Dept Oral & Maxillofacial Surg, IL-52621 Tel Hashomer, Israel
Tel Aviv Univ, Sch Dent Med, Dept Oral Pathol & Oral Med, IL-69978 Tel Aviv, IsraelUCL, Eastman Dent Inst, Oral Med Unit, Div Maxillofacial Diagnost Med & Surg Sci, London WC1X 8LD, England