CHEMISTRY OF PEPTIDES ASSOCIATED WITH MHC CLASS-I AND CLASS-II MOLECULES

被引:307
|
作者
RAMMENSEE, HG
机构
[1] Deutsches Krebsforschungszentrum, Abteilung Tumorvirus Immunologie (0620), D-69120 Heidelberg
关键词
D O I
10.1016/0952-7915(95)80033-6
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Recent developments have led to a clearer understanding of the association between peptides and MHC molecules. It is now clear that the peptides presented by MHC class I or class II molecules follow stringent rules that are different for each allelic product. The allele-specific interaction usually involves a sequence of nine amino acids spanning the MHC groove. For class I molecules, the entire peptide ligand is involved in allele-specific interaction with MHC but for class II, the peptides are longer and the nine amino acid sequence is roughly central to the peptide. Allele-specific interactions are brought about by anchoring peptide side chains in complementary pockets in the MHC groove. The sum of allele-specific peptide-MHC interaction requirements can be described as a motif, characterized by number, spacing and specificities of anchors, as well as the more degenerate preferences at non-anchor positions within the nonamer stretches. Such information is useful for T-cell epitope predictions.
引用
收藏
页码:85 / 96
页数:12
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