A case of clear cell adenoma of the thyroid associated with an anaplastic spindle cell carcinoma is reported. Histochemical and ultrastructural examination showed abundant cytoplasmic lipid inclusions and frequent cytoplasmic vesicles, which both may have contributed to the clear cell change. The follicular cell origin was demonstrated by thyroglobulin positivity using immunohistochemistry. We believe that this adenomatous lesion shows close similarities with the lipid-rich cell adenoma first described by Schroder et al. in 1984(8).
机构:
DUKE UNIV, MED CTR, DEPT PATHOL, SARAH W STEDMAN CTR NUTR STUDIES, DURHAM, NC 27710 USADUKE UNIV, MED CTR, DEPT PATHOL, SARAH W STEDMAN CTR NUTR STUDIES, DURHAM, NC 27710 USA
Guyton, JR
Klemp, KF
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DUKE UNIV, MED CTR, DEPT PATHOL, SARAH W STEDMAN CTR NUTR STUDIES, DURHAM, NC 27710 USADUKE UNIV, MED CTR, DEPT PATHOL, SARAH W STEDMAN CTR NUTR STUDIES, DURHAM, NC 27710 USA
机构:
Marshfield Clin Fdn Med Res & Educ, Dept Cardiol, 1000 North Oak Ave, Marshfield, WI 54449 USAMarshfield Clin Fdn Med Res & Educ, Dept Cardiol, 1000 North Oak Ave, Marshfield, WI 54449 USA
Rezkalla, Shereif H.
Holmes, David R., Jr.
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Mayo Clin, Div Internal Med & Cardiovasc Dis, 200 First St SW, Rochester, MN 55905 USAMarshfield Clin Fdn Med Res & Educ, Dept Cardiol, 1000 North Oak Ave, Marshfield, WI 54449 USA