THE INFLUENCE OF ANTIGEN ORGANIZATION ON B-CELL RESPONSIVENESS

被引：601

作者：

BACHMANN, MF ^{[1
]}

ROHRER, UH ^{[1
]}

KUNDIG, TM ^{[1
]}

BURKI, K ^{[1
]}

HENGARTNER, H ^{[1
]}

ZINKERNAGEL, RM ^{[1
]}

机构：

[1] UNIV ZURICH,DEPT PATHOL,INST EXPTL IMMUNOL,STERNWARTSTR 2,CH-8091 ZURICH,SWITZERLAND

来源：

SCIENCE | 1993年 / 262卷 / 5138期

关键词：

D O I：

10.1126/science.8248784

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The influence of antigen epitope density and order on B cell induction and antibody production was assessed with the glycoprotein of vesicular stomatitis virus serotype Indiana [VSV-G(IND)]. VSV-G(IND) can be found in a highly repetitive form in the envelope of VSV-IND and in a poorly organized form on the surface of infected cells. In VSV-G (IND) transgenic mice, B cells were unresponsive to the poorly organized VSV-G (IND) present as self antigen but responded promptly to the same antigen presented in the highly organized form. Thus, antigen organization influences B cell tolerance.

引用

页码：1448 / 1451

页数：4

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