2-Methyl-3-{4-[2-(1H-tetrazol-5-yl)ethylamino]phenyl}-3H-quinazolin-4-one

被引：3

作者：

Arulmurugan, Subramaniyan ^{[1
]}

Kavitha, Helen P. ^{[1
]}

机构：

[1] SRM Univ, Res Dept Chem, Ramapuram Campus, Madras 89, Tamil Nadu, India

来源：

MOLBANK | 2010年 / 03期

关键词：

quinazolinone; tetrazole; antimicrobial;

D O I：

10.3390/M695

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

This present work aims at synthesizing a novel tetrazole from quinazolinone. 3-(4-Aminophenyl)-2-methyl-3H-quinazolin-4-one is converted into a nitrile by reacting it with acrylonitrile and triton B. The nitrile on treatment with NaN3, NH4Cl and DMF yielded the corresponding tetrazole. The tetrazole obtained was characterized by IR, 1H NMR, EI-MS and elemental analysis. The compound was screened for antimicrobial activity against Staphylococcus aureus, Escherichia coli, Candida albicans and Aspergillus niger. The results of the study show that the compound possesses fairly good antimicrobial activity against the test organisms.

引用

页码：1 / 5

页数：5

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