ANTAGONISTIC EFFECTS OF RESERPINE ON D-TUBOCURARINE ACTION ON MOTOR FUNCTION OF RABBITS

被引：6

作者：

CARRIER, GO

PEGRAM, BL

CARRIER, O

机构：

[1] Department of Pharmacology, The University of Mississippi Medical Center, Jackson, MS

[2] The University of Texas Medical School at San Antonio, in San Antonio, TX

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1969年 / 6卷 / 02期

关键词：

d-Tubocurarine; Neuromuscular Junction; Reserpine;

D O I：

10.1016/0014-2999(69)90208-8

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

This study was designed to investigate the possibility that reserpine might exhibit an action at the neuromuscular junction by observing its interaction with d-tubocurarine. It was found that the dose of d-tubocurarine to cause paralysis of the hind limbs in normal rabbits was 0.176 ± 0.008 mg/kg. However, after the animals received various doses of reserpine, the required dose of d-tubocurarine needed increased significantly. Since reserpine does not alter neuromuscular transmission, it is possible that reserpine increases the excitability of the end plate. Thus, a larger dose of d-tubocurarine is needed for hind limb paralysis. © 1969.

引用

页码：125 / &

共 14 条

[1] ZUR PHARMAKOLOGIE DES RESERPIN, EINES NEUEN ALKALOIDS AUS RAUWOLFIA-SERPENTINA BENTH [J].