The Role of Intracellular Signaling Pathways in the Pathogenesis of Multiple Myeloma and Novel Therapeutic Approaches

被引：9

作者：

Kizaki, Masahiro ^{[1
]}

Tabayashi, Takayuki ^{[1
]}

机构：

[1] Saitama Med Univ, Saitama Med Ctr, Dept Hematol, 1981 Kamoda, Kawagoe, Saitama 3508550, Japan

来源：

JOURNAL OF CLINICAL AND EXPERIMENTAL HEMATOPATHOLOGY | 2016年 / 56卷 / 01期

关键词：

multiple myeloma; cytokines; signaling pathway; molecular-targeted therapy;

D O I：

10.3960/jslrt.56.20

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The introduction of novel agents, such as bortezomib, thalidomide, and lenalidomide, into daily practice has dramatically improved clinical outcomes and prolonged survival of patients with multiple myeloma (MM). However, despite these advanced clinical benefits, MM remains an incurable hematological malignancy. Therefore, development of new agents and novel therapeutic strategies is urgently needed. Recent advances toward understanding the mechanism of myeloma cell growth and drug resistance in the bone marrow milieu have provided clues for the development of next-generation agents aimed at improving patient outcomes. In this review article, we discuss new possible agents for the treatment of MM based on recent advances in the understanding of signaling pathways in myeloma cells. [J Clin Exp Hematop 56(1):20-27, 2016]

引用

页码：20 / 27

页数：8

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