O-DEMETHYLATION OF OPIOID DERIVATIVES WITH METHANE SULFONIC-ACID METHIONINE - APPLICATION TO THE SYNTHESIS OF NALOXONE AND ANALOGS

被引：17
|
作者：
ANDRE, JD
DORMOY, JR
HEYMES, A
机构：
[1] Sanofi-Chimie, Sisteron, cedex, Route de Gap
来源：
SYNTHETIC COMMUNICATIONS | 1992年 / 22卷 / 16期
关键词：
D O I：
10.1080/00397919208019086
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Naloxone 2 was obtained by demethylation of N-allylnoroxycodone 1 with methane sulfonic acid/methionine. This reagent is an excellent substitute for boron tribromide. It was used for the synthesis of analogous derivatives with variable results.
引用
收藏
页码：2313 / 2327
页数：15
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