CHANGES IN CONCENTRATION OF ESSENTIAL METALS IN KIDNEYS AND URINE AS INDEXES OF GENTAMICIN-NEPHROTOXICITY IN FEMALE WISTAR RATS

被引：11

作者：

CHMIELNICKA, J ^{[1
]}

SZYMANSKA, JA ^{[1
]}

BRZEZNICKA, EA ^{[1
]}

KALUZYNSKI, A ^{[1
]}

机构：

[1] MED ACAD LODZ, SCH PHARM, DEPT PATHOL, PL-90151 LODZ, POLAND

来源：

PHARMACOLOGY & TOXICOLOGY | 1992年 / 71卷 / 03期

关键词：

D O I：

10.1111/j.1600-0773.1992.tb00542.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Wistar rats were treated with gentamicin in single (80 mg/kg) or repeated doses (7 x 40 mg/kg) subcutaneously. Total protein as well as excretion of essential metals (Cu, Zn) with the urine were determined 24 hr after 1, 3 and 7 dosages as well as 3 and 7 days after the termination of administration. At the same time kidneys were examined histopathologically by light microscopy. Simultaneously, Cu, Zn and metallothionein levels in kidneys and liver were determined. Rats receiving gentamicin demonstrated progressive renal proximal tubular necrosis at the end of 7 days administration. At the same time elevated copper and zinc levels were observed in urine. These essential metals seem to be an indicator of gentamicin nephrotoxicity.

引用

页码：185 / 189

页数：5

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