BILIARY-EXCRETION OF FLAVANONES IN THE RAT

被引：28

作者：

HACKETT, AM

MARSH, I

BARROW, A

GRIFFITHS, LA

机构：

[1] Department of Biochemistry, University of Birmingham, Birmingham, B15 2TT

来源：

XENOBIOTICA | 1979年 / 9卷 / 08期

关键词：

D O I：

10.3109/00498257909087263

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. The major biliary metabolites of flavanones in the rat have been identified by chromatographic and spectral methods. 2. Evidence is presented that flavanones and flavanone glycosides, following oral or parenteral administration, undergo glucuronylation and are selectively excreted via the bile. 3. Flavanone glycosides but not unconjugated aglycones may be excreted to a significant extent in bile. 4. The percentage of parenterally administered flavanones excreted in bile varies inversely with the amount administered. © 1979 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：491 / 501

页数：11

共 30 条

[1]

BARROW A, 1974, XENOBIOTICA, V4, P1

[2] METABOLISM OF HYDROXYETHYLRUTOSIDES .3. FATE OF ORALLY-ADMINISTERED HYDROXYETHYLRUTOSIDES IN LABORATORY-ANIMALS - METABOLISM BY RAT INTESTINAL MICROFLORA INVITRO [J].