THE EFFECTS OF SCLERODERMA SERA ON ENDOTHELIAL-CELL SURVIVAL INVITRO

被引：7
作者：
ETOH, T [1 ]
IGARASHI, A [1 ]
IOZUMI, K [1 ]
ISHIBASHI, Y [1 ]
TAKEHARA, K [1 ]
机构：
[1] UNIV TOKYO,FAC MED,DEPT DERMATOL,7-3-1 HONGO,BUKYO KU,TOKYO 113,JAPAN
来源：
ARCHIVES OF DERMATOLOGICAL RESEARCH | 1990年 / 282卷 / 08期
关键词：
SCLERODERMA; PLATELETS; GROWTH FACTOR; ENDOTHELIAL CELL SURVIVAL; ANTINUCLEAR ANTIBODY;
D O I：
10.1007/BF00371946
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
The effects of sera and of platelet-poor plasma from patients with scleroderma on endothelial cell survival in vitro were studied. The survival ratio of rat heart endothelial cells was studied both in 10% test serum and in 10% platelet-poor plasma. Sera from patients with scleroderma decreased the survival ratio significantly when compared with sera from normal controls. In contrast, there was no significant difference between platelet-poor plasma from patients with scleroderma and that from normal controls. Our data indicate that platelets in the patients with scleroderma may cause vascular damage by affecting endothelial cell survival.
引用
收藏
页码：516 / 519
页数：4
相关论文
共 50 条
  • [21] Antiangiogenic effects of melatonin in endothelial cell cultures
    Alvarez-Garcia, Virginia
    Gonzalez, Alicia
    Alonso-Gonzalez, Carolina
    Martinez-Campa, Carlos
    Cos, Samuel
    MICROVASCULAR RESEARCH, 2013, 87 : 25 - 33
  • [22] Neuregulin-1β regulation of embryonic endothelial progenitor cell survival
    Safa, Radwan N.
    Peng, Xu-Yang
    Pentassuglia, Laura
    Lim, Chee Chew
    Lamparter, Mathias
    Silverstein, Cheri
    Walker, Jeremy
    Chen, Billy
    Geisberg, Carrie
    Hatzopoulos, Antonis K.
    Sawyer, Douglas B.
    AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2011, 300 (04): : H1311 - H1319
  • [23] Innate Immune Modulation Induced by EBV Lytic Infection Promotes Endothelial Cell Inflammation and Vascular Injury in Scleroderma
    Farina, Antonella
    Rosato, Edoardo
    York, Michael
    Gewurz, Benjamin E.
    Trojanowska, Maria
    Farina, Giuseppina Alessandra
    FRONTIERS IN IMMUNOLOGY, 2021, 12
  • [24] NADPH oxidase isoform selective regulation of endothelial cell proliferation and survival
    Peshavariya, Hitesh
    Dusting, Gregory J.
    Jiang, Fan
    Halmos, Lesley R.
    Sobey, Christopher G.
    Drummond, Grant R.
    Selemidis, Stavros
    NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2009, 380 (02) : 193 - 204
  • [25] Regulatory effects of soluble growth factors on choriocapillaris endothelial growth and survival
    Liu, XP
    Ye, XD
    Yanoff, MR
    Li, WY
    OPHTHALMIC RESEARCH, 1998, 30 (05) : 302 - 313
  • [26] KSHV-induced notch components render endothelial and mural cell characteristics and cell survival
    Liu, Ren
    Li, Xiuqing
    Tulpule, Anil
    Zhou, Yue
    Scehnet, Jeffrey S.
    Zhang, Shaobing
    Lee, Jong-Soo
    Chaudhary, Preet M.
    Jung, Jae
    Gill, Parkash S.
    BLOOD, 2010, 115 (04) : 887 - 895
  • [27] Anti-endothelial cell antibody rich sera from rheumatic heart disease patients induces proinflammatory phenotype and methylation alteration in endothelial cells
    Rastogi, Mukul
    Sarkar, Subendu
    Makol, Ankita
    Singh, Rana Sandip
    Saikia, Uma Nahar
    Banerjee, Dibyajyoti
    Chopra, Seema
    Chakraborti, Anuradha
    GENES & DISEASES, 2018, 5 (03) : 275 - 289
  • [28] Endothelial Progenitor Cell Mobilization in Preterm Infants With Sepsis Is Associated With Improved Survival
    Siavashi, Vahid
    Asadian, Simin
    Taheri-Asl, Masoud
    Keshavarz, Samaneh
    Zamani-Ahmadmahmudi, Mohamad
    Nassiri, Seyed Mahdi
    JOURNAL OF CELLULAR BIOCHEMISTRY, 2017, 118 (10) : 3299 - 3307
  • [29] Angiopoietin modulation of vascular endothelial growth factor: Effects on retinal endothelial cell permeability
    Peters, Swaantje
    Cree, Ian A.
    Alexander, Robert
    Turowski, Patric
    Ockrim, Zoe
    Patel, Jignesh
    Boyd, Shelley R.
    Joussen, Antonia M.
    Ziemssen, Focke
    Hykin, Philip G.
    Moss, Stephen E.
    CYTOKINE, 2007, 40 (02) : 144 - 150
  • [30] Pancreatic-carcinoma-cell-derived pro-angiogenic factors can induce endothelial-cell differentiation of a subset of circulating CD34+ progenitors
    Vizio, Barbara
    Biasi, Fiorella
    Scirelli, Tiziana
    Novarino, Anna
    Prati, Adriana
    Ciuffreda, Libero
    Montrucchio, Giuseppe
    Poli, Giuseppe
    Bellone, Graziella
    JOURNAL OF TRANSLATIONAL MEDICINE, 2013, 11
12345