THE EFFECTS OF SCLERODERMA SERA ON ENDOTHELIAL-CELL SURVIVAL INVITRO

被引：7
|
作者：
ETOH, T [1 ]
IGARASHI, A [1 ]
IOZUMI, K [1 ]
ISHIBASHI, Y [1 ]
TAKEHARA, K [1 ]
机构：
[1] UNIV TOKYO,FAC MED,DEPT DERMATOL,7-3-1 HONGO,BUKYO KU,TOKYO 113,JAPAN
来源：
ARCHIVES OF DERMATOLOGICAL RESEARCH | 1990年 / 282卷 / 08期
关键词：
SCLERODERMA; PLATELETS; GROWTH FACTOR; ENDOTHELIAL CELL SURVIVAL; ANTINUCLEAR ANTIBODY;
D O I：
10.1007/BF00371946
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
The effects of sera and of platelet-poor plasma from patients with scleroderma on endothelial cell survival in vitro were studied. The survival ratio of rat heart endothelial cells was studied both in 10% test serum and in 10% platelet-poor plasma. Sera from patients with scleroderma decreased the survival ratio significantly when compared with sera from normal controls. In contrast, there was no significant difference between platelet-poor plasma from patients with scleroderma and that from normal controls. Our data indicate that platelets in the patients with scleroderma may cause vascular damage by affecting endothelial cell survival.
引用
收藏
页码：516 / 519
页数：4
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