IDENTIFICATION OF DRUGS BY HIGH-PRESSURE LIQUID-CHROMATOGRAPHY WITH DUAL WAVELENGTH ULTRAVIOLET DETECTION

被引:96
作者
BAKER, JK
SKELTON, RE
MA, C
机构
[1] Department of Medicinal Chemistry, School of Pharmacy, University of Mississippi, University
来源
JOURNAL OF CHROMATOGRAPHY | 1979年 / 168卷 / 02期
关键词
D O I
10.1016/0021-9673(79)80012-6
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
Using three solvent-column systems, 101 drugs of forensic interest were characterized by their high-pressure liquid chromatographic relative retention times and by the ratio of their absorbances at 254 and 280 nm. Using relative retention times alone, only 9% of the drugs could be distinguished; while when both the retention times and absorbance ratios were used, 95% of the drugs could be distinguished. The compounds were also characterized by comparisons of their retention times on an adsorption column and a reversed-phase column, however this pair of discriminators were less useful than the former techniques. © 1979.
引用
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页码:417 / 427
页数:11
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