Angiogenesis in Inflammatory Bowel Disease

被引：99
作者：
Alkim, Canan [1 ]
Alkim, Huseyin [1 ]
Koksal, Ali Riza [1 ]
Boga, Salih [1 ]
Sen, Ilker [1 ]
机构：
[1] Sisli Hamidiye Etfal Training & Res Hosp, Dept Gastroenterol, TR-34360 Istanbul, Turkey
来源：
INTERNATIONAL JOURNAL OF INFLAMMATION | 2015年 / 2015卷
关键词：
D O I：
10.1155/2015/970890
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Angiogenesis is an important component of pathogenesis of inflammatory bowel disease (IBD). Chronic inflammation and angiogenesis are two closely related processes. Chronic intestinal inflammation is dependent on angiogenesis and this angiogenesis is modulated by immune systemin IBD. Angiogenesis is a very complex process which includesmultiple cell types, growth factors, cytokines, adhesion molecules, and signal transduction. Lymphangiogenesis is a new research area in the pathogenesis of IBD. While angiogenesis supports inflammation via leukocyte migration, carrying oxygen and nutrients, on the other hand, it has a major role in wound healing. Angiogenic molecules look like perfect targets for the treatment of IBD, but they have risk for serious side effects because of their nature.
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页数：10
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