SEPARATION OF ENANTIOMERS BY MICROCOLUMN LIQUID-CHROMATOGRAPHY WITH METHYLATED BETA-CYCLODEXTRIN AS MOBILE-PHASE ADDITIVE

被引：13
|
作者：
HU, RZ
TAKEUCHI, T
JIN, JY
MIWA, T
机构：
[1] XIAMEN UNIV, DEPT CHEM, XIAMEN 361005, PEOPLES R CHINA
[2] GIFU UNIV, FAC ENGN, GIFU 50111, JAPAN
来源：
ANALYTICA CHIMICA ACTA | 1994年 / 295卷 / 1-2期
关键词：
LIQUID CHROMATOGRAPHY; CYCLODEXTRINS; ENANTIOMER SEPARATION;
D O I：
10.1016/0003-2670(94)80348-X
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
Enantiomers can be separated by microcolumn liquid chromatography with methylated beta-cyclodextrin (beta-CD) as a mobile phase additive. Effects of the mobile phase composition on the retention behaviour of the analytes were examined. The separation factor achieved with heptakis(2,3,6-tri-O-methyl)-beta-CD as the chiral selector for 1,1'-binaphthyl-2,2'-diyl hydrogenphosphate enantiomers was up to 3. Heptakis(2,6-di-O-methyl)-beta-CD achieved poor enantioselectivities for the enantiomers examined.
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页码：173 / 179
页数：7
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