ENANTIOSELECTIVE AND DIASTEREOSELECTIVE CATALYSIS OF ADDITION-REACTION OF ALLYLIC SILANES AND STANNANES TO GLYOXYLATES BY BINAPHTHOL-DERIVED TITANIUM COMPLEX

被引：112

作者：

AOKI, S ^{[1
]}

MIKAMI, K ^{[1
]}

TERADA, M ^{[1
]}

NAKAI, T ^{[1
]}

机构：

[1] TOKYO INST TECHNOL,DEPT CHEM TECHNOL,MEGURO KU,TOKYO 152,JAPAN

来源：

TETRAHEDRON | 1993年 / 49卷 / 09期

关键词：

ASYMMETRIC CATALYSIS; ENANTIOCONTROL; DIASTEREOCONTROL; ALLYLIC SILANE; ALLYLIC STANNANE; CARBONYLADDITION REACTION; CARBONYL-ENE REACTION; GLYOXYLATE; BINAPHTHOL-DERIVED TITANIUM DIHALIDE; CHIRAL TITANIUM COMPLEX;

D O I：

10.1016/S0040-4020(01)80535-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Chiral titanium complex (1), prepared in situ from optically pure binaphthol and diisopropoxytitanium dihalide in the presence of molecular sieves, is shown to catalyze the addition reactions of crotylsilanes and -stannanes to glyoxylates to afford (syn)-alpha-hydroxy-beta-methyl esters in highly scalemic forms with high diastereoselectivity.

引用

页码：1783 / 1792

页数：10

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