SOLUBILITY OF ORGANIC-CHEMICALS IN OCTANOL, TRIOLEIN AND COD LIVER OIL AND RELATIONSHIPS BETWEEN SOLUBILITY AND PARTITION-COEFFICIENTS

The solubilities of 54 chemicals were measured in octanol, triolein and cod liver oil. Solubility of most chemicals increased with temperature between 4 and 20-degrees-C. Values of solubility in water and octanol/water partition coefficient (K(ow)) for these chemicals were compiled from the literature to examine their relationships with solubility in the three solvents. Regression analyses indicated highly significant relationships between (1) the chemicals' solubility in water and the three solvents, (2) solubility in water and K(ow), (3) solubility in other solvents and K(ow), and (4) solubility ratio of solvent/water and K(ow). Relationships 2-4 tend to be less well defined with increasing K(ow), this response may be attributed to K(ow), values that were derived by extrapolation or calculation. Further analyses between log solubility ratios and log K(ow), values up to 5.0, indicate a linear relationship where the regression coefficient was not significantly different from 1.0, and a regression intercept that included zero. This response would suggest K(ow), could be calculated from the solubility ratios of chemicals that are not miscible in solvents.