LIGAND-RECEPTOR INTERACTIONS DIRECTLY MEASURED WITH THE SURFACE FORCES APPARATUS

被引：7
作者：
HELM, CA
SCHMITT, FJ
ISRAELACHVILI, JN
KNOLL, W
机构：
[1] UNIV CALIF SANTA BARBARA,DEPT MAT,SANTA BARBARA,CA 93106
[2] UNIV CALIF SANTA BARBARA,DEPT CHEM & NUCL ENGN,SANTA BARBARA,CA 93106
[3] MAX PLANCK INST POLYMER RES,W-6500 MAINZ,GERMANY
来源：
MAKROMOLEKULARE CHEMIE-MACROMOLECULAR SYMPOSIA | 1991年 / 46卷
关键词：
D O I：
10.1002/masy.19910460114
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
Ligand-receptor interactions give rise to very strong bonds due to perfect geometrical fit. Using the Surface Forces Apparatus we have studied the interactions between membrane-bound biotin ligands and streptavidin receptors. We find an unusually strong short-range binding force associated with equally specific molecular rearrangements - both qualitatively and quantitatively unlike anything previously measured.
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页码：103 / 111
页数：9
相关论文
共 16 条
[1]   FORCES BETWEEN MODEL POLYPEPTIDES AND PROTEINS ADSORBED ON MICA SURFACES [J].
AFSHARRAD, T ;
BAILEY, AI ;
LUCKHAM, PF ;
MACNAUGHTAN, W ;
CHAPMAN, D .
COLLOIDS AND SURFACES, 1988, 31 :125-146
[2]  
Born M., 1975, PRINCIPLES OPTICS
[3]  
CEVC G, 1987, PHOSPHOLIPID BILAYER, pCH2
[4]   MOLECULAR MECHANISMS AND FORCES INVOLVED IN THE ADHESION AND FUSION OF AMPHIPHILIC BILAYERS [J].
HELM, CA ;
ISRAELACHVILI, JN ;
MCGUIGGAN, PM .
SCIENCE, 1989, 246 (4932) :919-922
[5]   LIGAND-RECEPTOR INTERACTIONS DIRECTLY MEASURED WITH THE SURFACE FORCES APPARATUS [J].
HELM, CA ;
SCHMITT, FJ ;
ISRAELACHVILI, JN ;
KNOLL, W .
MAKROMOLEKULARE CHEMIE-MACROMOLECULAR SYMPOSIA, 1991, 46 :103-111
[6]  
HELM CA, IN PRESS P NATL ACAD
[7]   MEASUREMENT OF THE DEFORMATION AND ADHESION OF SOLIDS IN CONTACT [J].
HORN, RG ;
ISRAELACHVILI, JN ;
PRIBAC, F .
JOURNAL OF COLLOID AND INTERFACE SCIENCE, 1987, 115 (02) :480-492
[8]   THIN-FILM STUDIES USING MULTIPLE-BEAM INTERFEROMETRY [J].
ISRAELAC.JN .
JOURNAL OF COLLOID AND INTERFACE SCIENCE, 1973, 44 (02) :259-272
[9]  
Israelachvili J.N., 1985, INTERMOLECULAR SURFA
[10]   CONTROLLED DEPOSITION OF LIPID MONOLAYERS AND BILAYERS ONTO MICA AND DIRECT FORCE MEASUREMENTS BETWEEN GALACTOLIPID BILAYERS IN AQUEOUS-SOLUTIONS [J].
MARRA, J .
JOURNAL OF COLLOID AND INTERFACE SCIENCE, 1985, 107 (02) :446-458
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