Some reactions of N-Ethylmaleimide

被引：306

作者：

Smyth, Derek G. ^{[1
]}

Nagamatsu, Atsuo ^{[1
]}

Fruton, Joseph S. ^{[1
]}

机构：

[1] Yale Univ, Dept Biochem, New Haven, CT 06520 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 1960年 / 82卷 / 17期

关键词：

D O I：

10.1021/ja01502a039

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The reactions of N-ethylmaleimide (NEM) with the amino group of peptides, with imidazole and with cysteine have been investigated. With the first two classes of compound, an IN-acylation reaction appears to occur, followed in the case of imidazole by a catalytic polymerization of NEM. With cysteine, reaction proceeds through addition of the thiol to the olefinic bond of NEM; in alkaline solution, the cysteine adduct undergoes all intramolecular transamidation reaction to form a thiazane derivative.

引用

页码：4600 / 4604

页数：5

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