BIOCHEMICAL MECHANISM OF SELECTIVE HEAT SENSITIVITY OF CANCER CELLS .2. STUDIES ON NUCLEIC ACIDS AND PROTEIN SYNTHESIS

被引：177

作者：

MONDOVI, B

AGRO, AF

ROTILIO, G

STROM, R

MORICCA, G

FANELLI, AR

机构：

[1] Institute of Biological Chemistry, University of Rome

[2] Regina Elena Institute for Cancer Research, Rome

来源：

EUROPEAN JOURNAL OF CANCER | 1969年 / 5卷 / 02期

关键词：

D O I：

10.1016/0014-2964(69)90060-7

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The effect of temperature in the range from 38° to 43°C upon incorporation of labeled precursors into DNA, RNA and protein of Novikoff and Morris 5123 hepatoma cells was investigated. A striking inhibition by temperature was found in both kind of tumor cells whereas regenerating liver cells were not affected. The temperature effect was observed also in cells from a human osteosarcoma. Cell free preparations were temperature insensitive. d-glucose added to the incubation mixture caused a marked inhibition. Filipin and ethanol were found to inhibit the incorporation into tumor cells at concentrations which did not significantly affect regenerating liver cells. A possible involvement of membranes in the mechanism of heat sensitivity of tumor cells is suggested. © 1969.

引用

页码：137 / &

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