SERUM ANTIBODY-RESPONSES IN OPISTHORCHIASIS

被引：26

作者：

AKAI, PS

PUNGPAK, S

CHAICUMPA, W

KITIKOON, V

RUANGKUNAPORN, Y

BUNNAG, D

BEFUS, AD

机构：

[1] UNIV CALGARY,DEPT MICROBIOL & INFECT DIS,CALGARY,AB,CANADA

[2] MAHIDOL UNIV,FAC TROP MED,BANGKOK,THAILAND

来源：

INTERNATIONAL JOURNAL FOR PARASITOLOGY | 1995年 / 25卷 / 08期

基金：

英国医学研究理事会;

关键词：

LIVER FLUKES; OPISTHORCHIASIS; OPISTHORCHIS VIVERRINI; ANTIBODIES; TREATMENT; PRAZIQUANTEL; METACERCARIA;

D O I：

10.1016/0020-7519(94)00212-7

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

We evaluated an enzyme-linked immunosorbent assay using crude parasite homogenates as a diagnostic test for Opisthorchis viverrini infection in humans. Serum antibody (Ab) responses to O. viverrini adult worm homogenate (AWH) and metacercaria homogenate (MH) were studied in 83 infected residents of an opisthorchiasis-endemic area in Thailand. Elevated levels of Ab persisted for over 1 year following curative treatment with praziquantel, and cross-reactivity to O. viverrini AWH and MH antigens was observed in sera from individuals with other parasitic infections. Serum Ab to crude AWH and MH are therefore unsuitable for immunodiagnosis since they may be non-specific and would not differentiate between ongoing and past infection.

引用

页码：971 / 973

页数：3

共 12 条

[1]

Ambriose-Thomas, Goullier, Peyron, Therapeutic results in opisthorchiasis with praziquantel in a reinfection-free environment in France, Arzneimmittelforschung/Drug Research, 34, pp. 1177-1179, (1984)

[2]

Elkins, Haswell-Elkins, Mairiang, Mairiang, Sithithaworn, Kaewkes, Bhudhisawasdi, Uttaravichien, A high frequency of hepatobiliary disease and suspected cholangiocarcinoma associated with heavy Opisthorchis viverrini infection in a small community in north-east Thailand, Transactions of the Royal Society of Tropical Medicine and Hygiene, 84, pp. 715-719, (1990)

[3]

Feldheim, Knobloch, Serodiagnosis of Opisthorchis viverrini infestation by an enzyme immuno-assay, Tropical Medicine and Parasitology, 33, pp. 8-10, (1982)

[4]

Harinasuta, Riganti, Bunnag, Opisthorchis viverrini infection: pathogenesis and clinical features, Arzneimmittelforschung/Drug Research, 34, pp. 1167-1169, (1984)

[5]

Ruenwongsa, Hutadilok, Yuthavong, Stimulation of Ca<sup>2+</sup> uptake in the human liver fluke Opisthorchis viverrini by praziquantel, Life Sciences, 32, pp. 2529-2534, (1983)

[6]

Sirisinha, Immunodiagnosis of human liver fluke infections, Asian Pacific Journal of Allergy and Immunology, 4, pp. 81-88, (1986)

[7]

Sirisinha, Puengtomwatanakul, Sobhon, Saitongdee, Wongpayabal, Mitranonde, Radomyos, Bunnag, Harinasuta, Alterations of the surface tegument of Opisthorchis viverrini exposed to praziquantel in vitro and in vivo, Southeast Asian Journal of Tropical Medicine and Public Health, 15, pp. 95-103, (1984)

[8]

Srivatanakul, Sontipong, Chotiwan, Parkin, Liver cancer in Thailand: temporal and geographic variations, Journal of Gastroenterology, 3, pp. 413-420, (1988)

[9]

Srivatanakul, Viyanant, Kurathong, Tiwawech, Enzyme-linked immunosorbent assay for detection of Opisthorchis viverrini infection, Southeast Asian Journal of Tropical Medicine and Public Health, 16, pp. 234-239, (1985)

[10]

Tawatsin, Sirisinha, Vajrasthira, Bunnag, Harinasuta, Evaluation of selected antihelminthic compounds for activity against Opisthorchis viverrini, Tropical Medicine and Parasitology, 35, pp. 85-90, (1984)

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