EFFECTS OF ALPHA-TOCOPHEROL IN RATS WITH A NEUROPATHIC PAIN SYNDROME

被引：1

作者：

DANILOVA, EI ^{[1
]}

GRAFOVA, VG ^{[1
]}

RESHETNYAK, VK ^{[1
]}

机构：

[1] RUSSIAN ACAD MED SCI, INST GEN PATHOL & PATHOL PHYSIOL, PATHOPHYSIOL PAIN LAB, MOSCOW 125315, RUSSIA

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 1994年 / 118卷 / 08期

关键词：

GENERATOR OF PATHOLOGICALLY ENHANCED EXCITATION; NEUROPATHIC PAIN SYNDROME; ALPHA-TOCOPHEROL; LIPID PEROXIDATION;

D O I：

10.1007/BF02444434

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The rat model of a neuropathic pain syndrome (transection of the sciatic nerve with encapsulation of its central end) was used to evaluate the efficacy of the antioxidant alpha-tocopherol in such syndromes. It was found that administration of alpha-tocopherol 3 days before nerve transection and then for 3 weeks thereafter it delayed the development of the pain syndrome, which subsequently tended to subside. In contrast, a 3-week alpha-tocopherol treatment started when the pain syndrome had already set in failed to influence its evolution. alpha-Tocopherol markedly reduced manifestations of inflammatory and degenerative processes in the denervated limb.

引用

页码：809 / 812

页数：4

共 19 条

[1] LIPID PEROXIDATION-INDUCED INHIBITION OF GAMMA-AMINOBUTYRIC ACID UPTAKE IN RAT-BRAIN SYNAPTOSOMES - PROTECTION BY GLUCOCORTICOIDS [J].