FORMULATION AND EVALUATION OF VINYLPYRROLIDONE VINYLACETATE COPOLYMER MICROSPHERES WITH GRISEOFULVIN

被引：13

作者：

VOJNOVIC, D

RUBESSA, F

BOGATAJ, M

MRHAR, A

机构：

[1] Department of Pharmaceutical Sciences, University of Trieste, 34100, Trieste

[2] Faculty of Natural Sciences and Technology, Department of Pharmacy, University of Ljubljana, Ljubljana

来源：

JOURNAL OF MICROENCAPSULATION | 1993年 / 10卷 / 01期

关键词：

D O I：

10.3109/02652049309015315

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Regular spherical microspheres of 220-260 mum average size have been prepared from vinylpyrrolidone/vinylacetate copolymer using a solvent evaporation method. Griseofulvin has been incorporated into these microspheres and its physical characterization has been carried out by differential scanning calorimetry (DSC), X-ray diffractometry and X-ray photoelectron spectroscopy. An increase of solubility was observed only with the 1:3 drug/polymer microspheres and the comparison of the dissolution profiles of microspheres with pure griseofulvin resulted in an enhancing effect. Furthermore the release rate of griseofulvin, incorporated into the microspheres, was shown to be biphasic and dependent upon the penetration of water into the microspheres, hydration and dissolution of the polymer and finally dissolution of the drug.

引用

页码：89 / 99

页数：11

共 6 条

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