SYNTHESIS OF MURAMYL DIPEPTIDE CONJUGATED WITH ACRIDINE-DERIVATIVES, SHOWING ANTI-HIV-1 AND ANTICANCER ACTIVITY

被引：0

作者：

DZIERZBICKA, K

KOLODZIEJCZYK, AM

WYSOCKASKRZELA, B

KOLODZIEJCZYK, AS

机构：

[1] GDANSK TECH UNIV,DEPT DRUG TECHNOL & BIOCHEM,PL-80952 GDANSK,POLAND

[2] UNIV GDANSK,DEPT ORGAN CHEM,PL-80952 GDANSK,POLAND

来源：

POLISH JOURNAL OF CHEMISTRY | 1994年 / 68卷 / 01期

关键词：

ACRIDINE DERIVATIVES; ANTI-HIV ACTIVITY; ANTITUMOR ACTIVITY; PEPTIDES;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A series of analogues of N-acetylmuramyl-L-alanyl-D-isoglutamine (MDP) conjugated at position 6 of the carbohydrate residue with some acridine derivatives were synthesized as potential anti-HIV-1 and/or anticancer agents. Preliminary screening data indicate that some of them (4a, 4d and 3e) exhibit anti-HIV-1 activity and some others, including the most active compound 3c, act as antitumor agents.

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页码：37 / 45

页数：9

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