SYNTHESIS OF MURAMYL DIPEPTIDE CONJUGATED WITH ACRIDINE-DERIVATIVES, SHOWING ANTI-HIV-1 AND ANTICANCER ACTIVITY

被引：0
|
作者：
DZIERZBICKA, K
KOLODZIEJCZYK, AM
WYSOCKASKRZELA, B
KOLODZIEJCZYK, AS
机构：
[1] GDANSK TECH UNIV,DEPT DRUG TECHNOL & BIOCHEM,PL-80952 GDANSK,POLAND
[2] UNIV GDANSK,DEPT ORGAN CHEM,PL-80952 GDANSK,POLAND
来源：
POLISH JOURNAL OF CHEMISTRY | 1994年 / 68卷 / 01期
关键词：
ACRIDINE DERIVATIVES; ANTI-HIV ACTIVITY; ANTITUMOR ACTIVITY; PEPTIDES;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A series of analogues of N-acetylmuramyl-L-alanyl-D-isoglutamine (MDP) conjugated at position 6 of the carbohydrate residue with some acridine derivatives were synthesized as potential anti-HIV-1 and/or anticancer agents. Preliminary screening data indicate that some of them (4a, 4d and 3e) exhibit anti-HIV-1 activity and some others, including the most active compound 3c, act as antitumor agents.
引用
收藏
页码：37 / 45
页数：9
相关论文
共 50 条
  • [1] Synthesis, anti-inflammatory and anticancer activity evaluation of some novel acridine derivatives
    Sondhi, Sham M.
    Singh, Jaiveer
    Rani, Reshma
    Gupta, P. P.
    Agrawal, S. K.
    Saxena, A. K.
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2010, 45 (02) : 555 - 563
  • [2] Synthesis, anticancer, anti-HIV-1, and antimicrobial activity of some tricyclic triazino and triazolo[4,3-e]purine derivatives
    Ashour, Fawzia A.
    Rida, Samia M.
    El-Hawash, Soad A. M.
    ElSemary, Mona M.
    Badr, Mona H.
    MEDICINAL CHEMISTRY RESEARCH, 2012, 21 (07) : 1107 - 1119
  • [3] Synthesis and anticancer activity evaluation of some acridine derivatives
    Arya, Surbhi
    Kumar, Anuj
    Kumar, Nikhil
    Roy, Partha
    Sondhi, S. M.
    MEDICINAL CHEMISTRY RESEARCH, 2015, 24 (05) : 1942 - 1951
  • [4] Synthesis and anticancer activity evaluation of some acridine derivatives
    Surbhi Arya
    Anuj Kumar
    Nikhil Kumar
    Partha Roy
    S. M. Sondhi
    Medicinal Chemistry Research, 2015, 24 : 1942 - 1951
  • [5] Synthesis of Bis-acridine Derivatives Exhibiting Anticancer and Anti-inflammatory Activity
    Sondhi, Sham M.
    Kumar, Sandeep
    Rani, Reshma
    Chakraborty, Ajanta
    Roy, Partha
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 2013, 50 (02) : 252 - 260
  • [6] Design, Synthesis and Anti-HIV-1 Activity of Modified Styrylquinolines
    Mahajan, Shivani
    Gupta, Shiv
    Jariwala, Nisha
    Bhadane, Deepali
    Bhutani, Late K. K.
    Kulkarni, Smita
    Singh, Inder Pal
    LETTERS IN DRUG DESIGN & DISCOVERY, 2018, 15 (09) : 937 - 944
  • [7] Design, synthesis, and bio-evaluation of novel triterpenoid derivatives as anti-HIV-1 compounds
    Takeuchi, Reon
    Ogihara, Kasumi
    Fujimoto, Junko
    Sato, Kohei
    Mase, Nobuyuki
    Yoshimura, Kazuhisa
    Harada, Shigeyoshi
    Narumi, Tetsuo
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2022, 69
  • [8] Synthesis and evaluation of A-seco type triterpenoids for anti-HIV-1 protease activity
    Wei, Ying
    Ma, Chao-Mei
    Hattori, Masao
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2009, 44 (10) : 4112 - 4120
  • [9] Synthesis, Biophysical Characterization, and Anti-HIV-1 Fusion Activity of DNA Quadruplex-based Inhibitors with Dipeptide MT Hook Conjuga-tion
    Xu, Liang
    Han, Zeye
    Ren, Hongqian
    CURRENT HIV RESEARCH, 2021, 19 (04) : 317 - 323
  • [10] Zinc coupling potentiates anti-HIV-1 activity of baicalin
    Wang, Q
    Wang, YT
    Pu, SP
    Zheng, YT
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2004, 324 (02) : 605 - 610
12345