EFFECT OF 5-AZA-2'-DEOXYCYTIDINE AND RETINOIC ACID ON DIFFERENTIATION AND C-MYC EXPRESSION IN HL-60 MYELOID LEUKEMIC-CELLS

被引：33

作者：

MOMPARLER, RL ^{[1
]}

DORE, BT ^{[1
]}

MOMPARLER, LF ^{[1
]}

机构：

[1] UNIV MONTREAL, DEPT PHARMACOL, MONTREAL H3C 3J7, QUEBEC, CANADA

来源：

CANCER LETTERS | 1990年 / 54卷 / 1-2期

关键词：

5-aza-2′-deoxycytidine; c-myc expression; combination chemotherapy; differentiation; leukemia; retinoic acid;

D O I：

10.1016/0304-3835(90)90086-D

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The antineoplastic effects of 5-aza-2′-deoxycytidine (5-AZA-CdR) and retinoic acid on human HL-60 myeloid leukemic cells were investigated. 5-AZA-CdR or retinoic acid reduced the clonogenicity and induced the differentiation of HL-60 leukemic cells. The effects produced by 5-AZA-CdR and retinoic acid in combination on clonogenicity and differentiation of HL-60 leukemic cells were additive. These agents in combination also produced an additive decrease in the mRNA expression of the c-myc. These data indicate that 5-AZA-CdR and retinoic acid in combination produce an additive antineoplastic effect against HL-60 human myeloid leukemic cells. © 1990.

引用

页码：21 / 28

页数：8

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