MODELS TO EXPLAIN DOSE-RESPONSE RELATIONSHIPS THAT EXHIBIT A DOWNTURN PHASE

被引：52

作者：

PLISKA, V

机构：

[1] V. Pliš, ETH Zürich.

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 1994年 / 15卷 / 06期

关键词：

D O I：

10.1016/0165-6147(94)90145-7

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Over a broad dose (or concentration) range, dose-response relationships frequently display a bell-shaped form. Mechanisms leading to this phenomenon may be manifold, but so far they have not been adequately identified. In this article, Vladimir Pliska discusses two models that are based on multiple-state cell-signalling pathways and enable an estimate of generally applicable descriptors. These can be used for expression of drug potency and for similar purposes.

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页码：178 / 181

页数：4

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