SIDEROPHORE PRESENCE IN SPUTA OF CYSTIC-FIBROSIS PATIENTS

被引:70
作者
HAAS, B
KRAUT, J
MARKS, J
ZANKER, SC
CASTIGNETTI, D
机构
[1] LOYOLA UNIV,DEPT BIOL,6525 N SHERIDAN RD,CHICAGO,IL 60626
[2] LUTHERAN GEN HOSP,CTR CYST FIBROSIS,PK RIDGE,IL 60068
关键词
D O I
10.1128/IAI.59.11.3997-4000.1991
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Sputum samples from the lungs of cystic fibrosis patients harboring Pseudomonas aeruginosa infections were collected and examined for the presence of the siderophore pyoverdine. Fluorescence quenching, due to the addition of ferric ion, as well as column and thin-layer chromatography results indicated that all samples contained the siderophore. Six samples furnished sufficient material after purification to allow us to obtain visible absorbance spectra. These spectra were characteristic of the ferrated analog of the P. aeruginosa pyoverdine, that is, ferripyoverdine, and in all cases they indicated a degree of ferration in excess of 50%. P. aeruginosa in the cystic fibrosis lung is thus iron stressed and responds by synthesizing pyoverdine, which subsequently binds ferric ion.
引用
收藏
页码:3997 / 4000
页数:4
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