INCREASED RISK OF CANCER IN PATIENTS WITH SYSTEMIC LUPUS-ERYTHEMATOSUS

被引：160

作者：

PETTERSSON, T

PUKKALA, E

TEPPO, L

FRIMAN, C

机构：

[1] UNIV HELSINKI,CENT HOSP,DEPT MED 4,UNIONINKATU 38,SF-00170 HELSINKI 17,FINLAND

[2] FINNISH CANC REGISTRY,HELSINKI,FINLAND

来源：

ANNALS OF THE RHEUMATIC DISEASES | 1992年 / 51卷 / 04期

关键词：

D O I：

10.1136/ard.51.4.437

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

To evaluate the risk of cancer in patients with systemic lupus erythematosus (SLE) a series of 205 consecutive patients (182 women and 23 men) were followed up for cancer through the files of the Finnish Cancer Registry. The follow up consisted of a total of 2340 person years. Fifteen cancers were diagnosed against 5.7 expected (relative risk (RR) 2.6, 95% confidence interval (CI) 1.5 to 4.4). Among the women there were four non-Hodgkin's lymphomas against 0.09 expected (RR 44, CI 11.9 to 111) and two soft tissue sarcomas against 0.04 expected (RR 49, CI 6.0 to 177). When evaluated by a case control study previous treatment with cytostatic drugs showed no influence on the occurrence of cancer in this series of patients with SLE.

引用

页码：437 / 439

页数：3

共 17 条

[1]

BATAILLE R, 1989, J RHEUMATOL, V16, P1023

[2] CANCER IN CONNECTIVE-TISSUE DISEASE [J].

BLACK, KA ;

ZILKO, PJ ;

DAWKINS, RL ;

ARMSTRONG, BK ;

MASTAGLIA, GL .

ARTHRITIS AND RHEUMATISM, 1982, 25 (09) :1130-1133

[3] INCREASED PROTOONCOGENE EXPRESSION IN PERIPHERAL-BLOOD LYMPHOCYTES FROM PATIENTS WITH SYSTEMIC LUPUS-ERYTHEMATOSUS AND OTHER AUTOIMMUNE-DISEASES [J].

BOUMPAS, DT ;

TSOKOS, GC ;

MANN, DL ;

ELEFTHERIADES, EG ;

HARRIS, CC ;

MARK, GE .

ARTHRITIS AND RHEUMATISM, 1986, 29 (06) :755-760

[4] MALIGNANCY IN A SERIES OF 70 PATIENTS WITH SYSTEMIC LUPUS-ERYTHEMATOSUS [J].

CANOSO, JJ ;

COHEN, AS .

ARTHRITIS AND RHEUMATISM, 1974, 17 (04) :383-390

[5]

CASH JM, 1991, CLIN EXP RHEUMATOL, V9, P109

[6]

COHEN A S, 1971, Bulletin on the Rheumatic Diseases, V21, P643

[7]

FAUCI AS, 1978, J IMMUNOL, V121, P1473

[8]

GREEN JA, 1978, LANCET, V2, P753

[9]

HAYAKAWA K, 1988, ANNU REV IMMUNOL, V6, P194

[10] EXCESS RISK OF LYMPHOMAS, LEUKEMIA AND MYELOMA IN PATIENTS WITH RHEUMATOID-ARTHRITIS [J].

ISOMAKI, HA ;

HAKULINEN, T ;

JOUTSENLAHTI, U .

JOURNAL OF CHRONIC DISEASES, 1978, 31 (11) :691-696

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