CHIRAL SEPARATIONS AND MODES OF ASSOCIATION OF HYDROGEN-BONDING MOLECULES

The state of the art of chiral chromatographic resolution is briefly reviewed, with emphasis on the procedures introduced in the author's laboratory. This is followed by a discussion of proposed mechanisms of resolution in systems in which selectors and selectands interact by hydrogen bonding. Essentially, it is proposed that resolution models should be based on associates of the most stable conformations of both the stationary phase and the solute. Data available from minimal energy computations and from hydrogen bonding modes in biological systems should be used for this purpose.