COMPARISON OF METHODS FOR DETERMINATION OF SALICYCLIC ACID IN BUFFERED ASPIRIN TABLETS

被引：21

作者：

GUTTMAN, DE

SALOMON, GW

机构：

[1] Department of Pharmaceutics, School of Pharmacy, State University of New York at Buffalo, Buffalo, New York

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1969年 / 58卷 / 01期

关键词：

Buffered aspirin tablets—assay methods comparison; Citric acid procedure—free salicylic acid determination; Column chromatography—separation; Salicylic acid analysis—buffered tablets; UV spectrophotometry—analysis;

D O I：

10.1002/jps.2600580128

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

New procedures are described for the determination of the free salicylic acid content and the total nonaspirin salicylate content of buffered aspirin tablets. Free salicylic acid and total nonaspirin salicylate contents of a number of tablet samples were determined. The new procedure for nonaspirin salicylates yielded results which were in close agreement with those found using the Levine and Weber method. No relationship was found between the free salicylic acid content and the total nonaspirin salicylate content of buffered tablets. The USP XVII test method for free salicylic acid yielded results which were consistently and significantly lower than those found with the other methods studied. Copyright © 1969 Wiley‐Liss, Inc., A Wiley Company

引用

页码：120 / &

共 6 条

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WEBER, JD .

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[6]

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