AN INVESTIGATION OF ANTIHISTAMINIC ACTIVITY AND GASTRIC ULCERATION

被引：28

作者：

ALPHIN, RS

WARD, JW

机构：

[1] A.H. Robins Research Laboratories, Department of Pharmacological Research, Richmond, VA

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1969年 / 6卷 / 01期

关键词：

Antihistamines; Gastric ulceration; Protection;

D O I：

10.1016/0014-2999(69)90066-1

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

An investigation of antihistaminic activity and gastric ulceration has been done in guinea pigs and rats. Gastric ulcers were produced in guinea pigs by histamine and restraint procedures, while pyloric-ligation and reserpine were used in rat experiments. Brompheniramine, AHR-224-B, tripelenamine HCl, cyproheptadine HCl and promethazine HCl were effective in preventing histamine-induced ulceration in guinea pigs. Glycopyrrolate, a potent anticholinergic, was ineffective. Brompheniramine, the most potent antihistamine (against histamine-induced ulceration), was further investigated for its effects on gastric ulceration induced by other procedures. In restraint-induced ulcers in guinea pigs, the drug was without protective effect. When the gastric ulceration was produced in rats by pyloric-ligation or reserpine, this antihistamine, in contrast to glycopyrrolate, did not exert a protective action. These studies show that several antihistamines are effective antagonists to histanine-induced gastric ulceration in guinea pigs. The effectiveness of certain pharmacological agents (antihistamine or anticholinergic) in preventing gastric ulceration is determined to a large degree by the method employed to produce the ulceration. © 1969.

引用

页码：61 / &

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